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ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD057928 | Pride
Human pdac organoids 
ProteomicsProteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids
Extracellular vesicles (EVs) are produced and released by both healthy and malignant cells and bear markers indicative of ongoing biological processes. In the present study we utilized high resolution flow cytometry to detect EVs in the plasma of patients with pancreatic ductal adenocarcinoma (PDAC)...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030325 | Pride
Ev markers Mass spectrometry Extracellular vesicles High resolution flow cytometry Biomarkers Pdac Pancreatic ductal adenocarcinoma 
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057888 | Pride
Murine pdac organoids 
ProteomicsIdentification of KRas interactors in murine PDAC organoid models
KRas is one of the most prevalent mutations in pancreatic cancer and derives diverse signalling cascades to support tumour initiation and progression. Pancreatic ductal adenocarcinoma (PDAC) is the most diagnosed type of pancreatic cancer and is characterized to have a very dense stromal rigidity. T...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-11 | PXD069991 | Pride
Organoids Lc-ms-ms Pdac Mass spectrometry Pancreatic cancer Kras 
UnknownReconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset.
Not available
S-EPMC10821902 | biostudies-literature
UnknownQuantitative Live Imaging Reveals Phase Dependency of PDAC Patient-Derived Organoids on ERK and AMPK Activity.
Not available
S-EPMC11875792 | biostudies-literature
TranscriptomicsInhibition of ketohexokinase C isoform impairs the development of PDAC tumors
the genetic inactivation of Khk-C enhanced the survival of KPC-driven PDAC model even in absence of high fructose diet. Moreover Khk-C knock out decreased the viability of KPC organoids and cancer cells, the migratory capability of PDAC cells in vitro and the growth of KPC cells in vivo in a cell au...
ORGANISM(S): Mus musculus 
2023-07-07 | E-MTAB-12746 | biostudies-arrayexpress
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057829 | Pride
Murine pancreatic exocrine organoids 
UnknownIn-vitro model to mimic T cell subset change in human PDAC organoid co-culture.
Not available
S-EPMC10587248 | biostudies-literature
UnknownP4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids.
Not available
S-EPMC12123483 | biostudies-literature
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