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MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
MetabolomicsMetabolic Database of Sepsis
SepsisLiMetDB is a curated metabolomics database characterizing sepsis-induced liver injury, comprising 2,894 metabolites identified from 88 longitudinal clinical samples (20 healthy controls, 36 sepsis without liver injury, 32 sepsis with liver injury) across four disease progression timepoints (D1...
2026-08-03 | MTBLS14459 | MetaboLights
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
TranscriptomicsMicroRNA profiling by array of human sepsis patients after surgery identifies miR-150 as a plasma prognostic marker
MicroRNA fingerprints in sepsis patients after surgery identify miR-150 as a plasma prognostic marker
ORGANISM(S): Homo sapiens 
2009-10-27 | E-TABM-713 | biostudies-arrayexpress
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
MetabolomicsSerum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

Serum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

2026-05-18 | MTBLS14016 | MetaboLights
TranscriptomicsAn integrated transcriptome and expressed variant analysis of sepsis survival and death
Background: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at gr...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-63042 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis
Expression data from Total RNA extracted from murine spleen. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) flui...
ORGANISM(S): Mus musculus 
2010-11-22 | E-GEOD-24357 | biostudies-arrayexpress
TranscriptomicsWhole blood mRNA transcription profiling of host immune changes in neonatal sepsis during vancomycin therapy
The purpose of this study was to investigate changes in host gene expression profiles of neonatal infants with sepsis prior to the initiation of and during vancomycin therapy, to identify treatment-responsive genes and signature pathways associated with recovery from neonatal sepsis. The study analy...
ORGANISM(S): Homo sapiens 
2025-11-25 | E-MTAB-15687 | biostudies-arrayexpress
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma (PBMC)
The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on ...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49754 | biostudies-arrayexpress
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