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MetabolomicsUntargetted lipidomics dataset: LC-MS analysis in two postmortem brain areas of healthy individuals and schizophrenia patients.

Schizophrenia is a common mental illness. It is a complex disorder with many symptoms and cognitive impairments. Despite extensive study, the molecular mechanisms of this disease are still unknown. Present time studies on the lipid composition of the human brain are extremely fragmented. Of the p...

2024-06-04 | MTBLS8955 | MetaboLights
ProteomicsProteomic Characterization of Post-Mortem Human Brain Tissue Following Ultracentrifugation-based Subcellular Fractionation
Proteomic characterization of human brain tissue is increasingly utilized to identify potential novel biomarker and drug targets for a variety of neurological diseases. In whole tissue studies, results may be driven by changes in the proportion of the largest and most abundant organelles or tissue c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-06 | PXD027456 | Pride
Subcellular fractionation Human brain Label free quantitation Alzheimer's disease 
TranscriptomicsComparison of post-mortem tissue from brain BA10 region between schizophrenic and control patients.
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong...
ORGANISM(S): Homo sapiens 
2009-08-13 | E-GEOD-17612 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal corte...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-5389 | biostudies-arrayexpress
TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of post-mortem human brain to investigate gender specific gene expression
Gender differences in brain development and in the prevalence of neuropsychiatric disorders such as depression have been reported. Gender differences in human brain might be related to patterns of gene expression. Microarray technology is one useful method for investigation of gene expression in bra...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2164 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human post-mortem brain tissue of the frontal lobe from patients with FTD and healthy controls
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotempor...
ORGANISM(S): Homo sapiens 
2023-02-17 | E-MTAB-12647 | biostudies-arrayexpress
ProteomicsInter-regional proteomic profiling of the human brain using optimized protein extraction method from formalin-fixed tissue to identify signaling pathways
Proteomics offers vast potential to study the molecular regulation of the human brain. Formalin fixation is a common method for preserving human tissue, however, presents challenges for proteomic analysis. In this study we compared the efficiency of two different protein extraction buffers on three ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD039808 | Pride
Formalin-fixed Proteomics Brain Mass spectrometry Pathways Protein Region Method Human Signaling 
TranscriptomicsCAGE-seq of human post-mortem brain tissue of the frontal lobe from patients with FTD and healthy controls
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotempor...
ORGANISM(S): Homo sapiens 
2023-02-26 | E-MTAB-12646 | biostudies-arrayexpress
TranscriptomicsSpatio-temporal transcriptome of the human brain
The development of the human brain is a complex and precisely regulated process that unfolds over a protracted period of time. Human-specific features of this process, especially the ways in which highly complex neural circuits of the cerebral cortex form, are likely to be important factors in the e...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-25219 | biostudies-arrayexpress
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