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ProteomicsPhysiological shear stress markedly alters the proteomic response to hypoxia in human pulmonary microvascular endothelial cells
Physiological shear stress, produced by blood flow, homeostatically regulates the phenotype of pulmonary endothelial cells exerting anti-inflammatory and anti-thrombotic actions and maintaining normal barrier function. In the pulmonary circulation hypoxia, due to high altitude or diseases such as CO...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036260 | Pride
Shear stress Copd Human pulmonary microvascular endothelial cells Hypoxia 
ProteomicsTranscriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells
There is marked sexual dimorphism displayed in the onset and progression of pulmonary hypertension (PH). Females more commonly develop pulmonary arterial hypertension (PAH), however, females with PAH and other types of PH have better survival than males. Pulmonary microvascular endothelial cells pla...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD046787 | Pride
Sex differences Human pulmonary microvascular endothelial cells Hypoxia Pulmonary hypertension 
ProteomicsPulmonary microvascular endothelial cells support alveolar epithelial growth via bone morphogenetic protein 6 secretion
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and emphysema development, associated with enhanced tissue destruction and defective repair. Supporting cells in the alveolar niche play a crucial role in guiding the activation of alveolar epithelial pro...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD053755 | Pride
Bmp6 Pulmonary microvascular endothelial cells Copd 
TranscriptomicsMultiple waves of transcriptome changes during extended hypoxic induction in human pulmonary microvascular endothelial cells
We profile the expression pattern of human pulmonary microvascular endothelial cells (HPMECs) at different time points of hypoxic stress. Through mRNA-seq, we identify functional waves of minor gene up-regulation at 8 and 24h hypoxia exposure followed by a massive wave of transcriptional activation ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53510 | biostudies-arrayexpress
TranscriptomicsExpression data from BMP9-treated human dermal microvascular endothelial cells (HMVEC-D)
BMP9 signaling has been implicated in hereditary hemorrhagic telangiectasia and vascular remodeling, acting via the HHT target genes, endoglin and ALK1. This study sought to identify endothelial BMP9-regulated proteins that could affect the HHT phenotype. Gene ontology analysis of cDNA microarray da...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-40960 | biostudies-arrayexpress
GenomicsImpact of human miR-887-3p on gene expression in human pulmonary microvascular endothelial cells
Impact of human miR-887-3p on gene expression in human pulmonary microvascular endothelial cells
PRJNA609160 | ENA
TranscriptomicsTranscriptomic analysis of microvascular response to carbon and photon irradiation
The aim of our study is to investigate and compare the effects of carbon and photon irradiation on microvascular endothelial cells. Therefore we irradiated human pulmonary microvascular endothelial cells (HPMEC) with either 2Gy Carbon or 6Gy Photon (bioequivalent doses) and performed microarray anal...
ORGANISM(S): Homo sapiens 
2023-11-02 | E-MEXP-3956 | biostudies-arrayexpress
TranscriptomicsHuman Toll-Like Receptors Pathway Array Data
Endothelial cell (EC) Toll-like receptor 2 (TLR2) activation upregulates the expression of inflammatory mediators and of TLR2 itself, and modulates important endothelial functions, including coagulation and permeability. We defined TLR2 signaling pathways in ECs, and tested the hypothesis that TLR2 ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress
GenomicsTranscriptomics revealed sex differences in human pulmonary microvascular endothelial cells in normoxia and hypoxia
Transcriptomics revealed sex differences in human pulmonary microvascular endothelial cells in normoxia and hypoxia
PRJNA976643 | ENA
UnknownHuman herpesvirus-8 infection of primary pulmonary microvascular endothelial cells.
Not available
S-EPMC2586046 | biostudies-literature
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