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MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
MetabolomicsMulti-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
MetabolomicsIntegrated Transcriptomic and Metabolomic Reveals VASH1 Influences Pork Quality by Regulating Skeletal Muscle Glycolysis

Glycolytic potential (GP) is an important index for evaluating meat quality in the pig industry, since high muscle glycogen content generally leads to rapid postmortem glycolysis, which contributes to low meat quality. However, there are few researches to elucidate the genetic mechanisms underlie...

2025-10-24 | MTBLS13217 | MetaboLights
MetabolomicsHippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism
Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect agains...
2026-07-17 | MTBLS15070 | MetaboLights
TranscriptomicsEffects of a 8-week training on human skeletal muscle
Context: Exercise training is a plausible model for identification of molecular mechanisms that cause metabolic-related changes in human skeletal muscle. Objective: The goal was to explore the molecular basis of the adaptation of skeletal muscle to exercise training. Design and Intervention: Obes...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-40551 | biostudies-arrayexpress
MetabolomicsDelayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle

Exercise is fundamental to healthy aging, yet the degree to which it mitigates age-related molecular changes and how varying physical fitness levels influence the molecular response to exercise with age remain unclear. To address this, we performed transcriptomics, lipidomics, and metabolomics on...

2026-04-09 | MTBLS12824 | MetaboLights
MetabolomicsMicrobiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated meta...

2026-05-09 | MTBLS13787 | MetaboLights
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