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MetabolomicsRegional Immunological and Microbial Characterization of Peyer's Patches in the Small Intestine of Bactrian Camels

Background: Our earlier research showed that Bactrian camels have a unique lymph aggregation structure that is similar to ileal Peyer's patches (PPs) and plays a role in the mucosal immunology of the digestive tract. However, Bactrian camels exhibit PPs not only in the ileum but also in all segme...

2024-11-11 | MTBLS10376 | MetaboLights
ProteomicsConstruction of small intestine-like tissue by reproducing interstitial flow on-chip
Significant progress has been recently achieved in generating in vitro human small intestine models. Nonetheless, there remains ample opportunity for enhancement, both in terms of structure and function, within the current model. In this study, our objective is to construct a multilayered small inte...
ORGANISM(S): Homo Sapiens (human) 
2024-11-16 | PXD047318 | JPOST Repository
MetabolomicsMetabolic network construction reveals probiotic-specific colonization resistance in a synthetic small intestinal community

The gut microbiota is essential to host health. Probiotics can be used as a microbiota targeted therapy to improve host health. However, probiotic molecular mechanisms of action and probiotics targeting the small intestinal microbiota are often not elucidated. In this study, we construct a three ...

2024-09-26 | MTBLS7370 | MetaboLights
TranscriptomicsTranscription profiling of human samples from intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome wide gene expression in the small intestine
Human intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome-wide gene expression in the small intestine, in order to obtain detailed information about intestinal transcriptomics in vivo.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-325 | biostudies-arrayexpress
TranscriptomicsSexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
There is increasing appreciation for sexually dimorphic effects, but the molecular mechanisms underlying these effects are only partially understood. In the present study, we explored transcriptomics and epigenetic differences in the small intestine and colon of prepubescent male and female mice. In...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-57516 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 ca...
2021-07-13 | MTBLS440 | MetaboLights
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain.
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet ...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-8582 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in the small intestine of IE-Cpr-null mice
The NADPH-cytochrome P450 reductase (CPR) is essential for the functioning of microsomal cytochrome P450 (P450) monoxygenases. The biological functions of the CPR-dependent enzymes in the intestine are not known, despite the vast knowledge available on the biochemical properties of the various oxyge...
ORGANISM(S): Mus musculus 
2012-04-10 | E-GEOD-35293 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine reveals fasting induces a biphasic adaptive metabolic response
Background; The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results; In...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-8019 | biostudies-arrayexpress
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