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MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
TranscriptomicsmicroRNA expression data from human corneal epithelial cells exposed to media, human tear, media + P. aeruginosa antigens, tear + P. aeruginosa antigens
Exposure to tear fluid can enhance corneal epithelial cells' ability to resist bacterial virulence mechanisms by upregulating epithelial-derived innate defense genes. The aim of this study was to further elucidate the mechanisms by which tear fluid modulates epithelial cell susceptibility to P. aeru...
ORGANISM(S): Homo sapiens 
2012-07-13 | E-GEOD-39341 | biostudies-arrayexpress
ProteomicsSystematic Investigation of Targeted Analysis of Metabolites and Proteins in Tear Fluid
Since the sampling of tear fluid seems rather variable we sought to evaluate a protocol for combined metabolomic and proteomic analyses with regard to clinical applicability. Tear fluid was taken from twelve human volunteers at different time points using specially designed Schirmer strips. Followin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008536 | Pride
Tear fluid 
ProteomicsHuman tear (Diabetic macular edema), LC-MSMS
Tear proteome changes in diabetic macular edema with treatment. The constitution of tear protein change was assessed for difference in treatment response
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061821 | Pride
Lc-msms Diabetic macular edema Human tear 
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsAmplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the onset of symptoms by maintaining a healthy lifestyle and controlling modifiable risk factors. Therefore, more sensitive, relatively inexpensive, non-invasive, and simple screening tools are req...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042142 | Pride
Alzheimer’s disease Immunoassay Magnetic nanoparticles Polymeric nanoprobes Tear fluid 
ProteomicsProteomic analysis of single tears from healthy human subjects
23 volunteers were recruited for this study. Tears were collected using microcapillary tubes (MCT). For each volunteer, a single tear sample was taken from one eye. For two of these volunteers, the procedure was performed in the morning (9-10 AM) and in the afternoon (5-6 PM) on the same day, once a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-25 | MSV000087703 | MassIVE
ProteomicsAlterations in tear proteomes of adults with pre-diabetes and type 2 diabetes mellitus but without diabetic retinopathy
This study aims to explore the impact of type 2 diabetes mellitus (T2DM) on tear proteome, specifically investigating whether alterations occur before the development of diabetic retinopathy. Flush tear samples were collected from healthy subjects (n=13), subjects with preDM (n=16) and T2DM (n=18). ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD062366 | Pride
Tear film  type 2 diabetes mellitus  mass spectrometry  proteomics Machine learning. 
ProteomicsEffect of acupuncture on tear proteomics in patients with video display terminal-related dry eye
In our study, the tear proteome was compared with identify possible mechanisms and biomarkers for predicting acupuncture effectiveness in VDT-related dry eye. The results showed that the Ocular Surface Disease Index (OSDI) scores were significantly different between the acupuncture group (AC group) ...
ORGANISM(S): Homo Sapiens 
PXD051759 |
ProteomicsHuman Tear using MALDI-TOF-MS for Dry Eye syndrome
Tears are a biological fluid that has diagnostic potential for ocular diseases. Extracellular vesicles (EVs), wildly detected in various biofluids including tears, are nanoparticles released by living cells and considered as promising detection sources for non-invasive liquid biopsy. Understanding t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD020217 | Pride
Human Maldi-tof ms Tear Dry eye syndrome Extracellular vesicles 
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