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MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
TranscriptomicsTranscriptome changes affecting hedgehog and cytokine signalling in the umbilical cord in late pregnancy: implications for disease risk
BACKGROUND: Babies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study. We investigated...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37100 | biostudies-arrayexpress
TranscriptomicsGene expression in human umbilical cord endothelial cells following FoxP1 knockdown
To search for genes regulated by the transcription factor Forkhead box Protein P1 (FoxP1) in endothelial cells, we transfected human umbilical cord endothelial cells (HUVECs) with a combination of three siRNA oligonucleotides directed against human FoxP1 . Human umbilical vein endothelial cells (HU...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-32968 | biostudies-arrayexpress
TranscriptomicsGene expression in human umbilical cord vein and artery endothelial cells under physiological chronic normoxia (3% O2, PCN) and standard culture normoxia (21% O2, SCN)
Endothelial cells, and many other types of cells too, physiologically reside in low O2 environments (~ 2-13% O2 or 15-60 mmHg pO2; [PCN]) relevantly to atmospheric O2 (~ 21% or 160 mmHg pO2 at sea level) in vivo. Such PCN is critical for endothelial functions. The majority of our current knowledge ...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-49958 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of human umbilical cord-derived MSC (UCX) in normoxia and hypoxia
Human umbilical cord matrix-derived mesenchymal stromal cells (UCM-MSC) are advantageous since can be easily obtained and display special interest as universal and feasible add-on therapy for myocardial infarction (MI). In this study, UCM-MSC from two umbilical cords, UC-A and UC-B, were transplante...
ORGANISM(S): Homo sapiens 
2021-01-07 | E-MTAB-9978 | biostudies-arrayexpress
TranscriptomicsDNA microarrays of 4 human iPSC cell lines and the ESC cell line H9
Documents of DNA expression of 4 human induced pluripotent stem cell (iPSC) lines from umbilical cord mesenchymal cells (UMCs) and amniotic mesenchymal cells (AMCs). We used microarrays to identify similarity between 4 iPSC cell lines and the human embryonic stem cell (ESC) line H9. 2 AMC iPSC cell ...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-20581 | biostudies-arrayexpress
TranscriptomicsHuman umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes [human]
Human and rat umbilical cord matrix mesenchymal stem cells (UCMSC) possess the ability to control the growth of breast carcinoma cells. Comparative analyses of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Their different tu...
ORGANISM(S): Homo sapiens 
2015-08-06 | E-GEOD-64827 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells: meta-analysis
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-18 | E-GEOD-20125 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-25 | E-GEOD-20126 | biostudies-arrayexpress
ProteomicsProteomic analysis of EVs from human UCMSC
Proteomic analysis of EVs from human Umbilical Cord Mesenchymal Stem Cells
ORGANISM(S): Homo Sapiens 
2024-09-02 | PXD055465 |
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