Sort   by:  
 Page size 
GenomicsMultiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
PRJNA630502 | ENA
OtherMultiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin. Despite VKOR’s pivotal role in coagulation, its structure and active site remain poorly understood. Here, we ...
ORGANISM(S): synthetic construct Homo sapiens 
2020-08-10 | GSE149922 | GEO
UnknownMultiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.
Not available
S-EPMC7462613 | biostudies-literature
UnknownImproved expression of recombinant human factor IX by co-expression of GGCX, VKOR and furin.
Not available
S-EPMC3947961 | biostudies-literature
UnknownStructural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases.
Not available
S-EPMC9346089 | biostudies-literature
UnknownPhylogeny of the Vitamin K 2,3-Epoxide Reductase (VKOR) Family and Evolutionary Relationship to the Disulfide Bond Formation Protein B (DsbB) Family.
Not available
S-EPMC4555120 | biostudies-literature
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
Unknown<i>In Silico</i> and <i>In Vitro</i> Studies of Potential Novel Vitamin K Epoxide Reductase (VKOR) Inhibitors Suggest an Updated Structure-Activity Relationship.
Not available
S-EPMC12224098 | biostudies-literature
UnknownHuman vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
Not available
S-EPMC3083210 | biostudies-literature
ProteomicsOptimized Digestion Conditions for Membrane Protein Foot-printing and Mass Spectrometry Analysis
Integral membrane proteins (IMPs), which constitute 50–60% of drug targets, play essen-tial roles in numerous biological processes but remain underrepresented in conventional bottom-up and in structural proteomics owing to their hydrophobicity and resistance to proteolysis. Although advances in IMPs...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD072461 | Pride
Membrane protein  vitamin k epoxide reductase (vkor)  mass spectrometry  protein footprinting  filter-aided sample preparation (fasp) Membrane protein digestion 
Sort   by:  
 Page size