Sort   by:  
 Page size 
TranscriptomicsHuman hepatocyte metaplasia in injured humanized mouse livers
The goal of this experiment was to test whether human hepatocytes could give rise to biliary-like progenitor cells in an in vivo context. Here Fah-/- Il2ry-/- Rag2-/-NOD mouse livers were humanized with human hepatocytes. Only hepatocytes engraft in the Fah-/- mouse at detectable levels in this mod...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-58679 | biostudies-arrayexpress
UnknownTargeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.
Not available
S-EPMC3610702 | biostudies-literature
GenomicsComparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice) [chimeric humanized liver experiments]
Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice) [chimeric humanized liver experiments]
PRJNA627702 | ENA
TranscriptomicsHuman hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver [Mouse Liver Experiments]
High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR) activator, have been shown to produce hepatocellular tumors in rodents by a mitogenic mode of action (MOA) involving CAR activation. The effect of 1 week dietary treatment with NaPB on liver weight and histopathology...
ORGANISM(S): Mus musculus 
2014-08-29 | E-GEOD-57055 | biostudies-arrayexpress
UnknownInvestigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver.
Not available
S-EPMC11818726 | biostudies-literature
GenomicsHuman hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver [Chimeric Liver Experiments]
Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver [Chimeric Liver Experiments]
PRJNA245333 | ENA
TranscriptomicsHBV_HCV_mouse
Genome wide DNA methylation analysis using 20 human hepatocyte chimeric mice after hepatitis viral infection.
ORGANISM(S): Mus musculus 
2014-01-03 | E-MTAB-1474 | biostudies-arrayexpress
UnknownChimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity.
Not available
S-EPMC8521358 | biostudies-literature
TranscriptomicsComparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice) [chimeric humanized liver experiments]
Using a chimeric mouse humanized liver model, we provided evidence that human hepatocytes are refractory to the mitogenic effects of rodent constitutive androstane receptor (CAR) activators. To evaluate the functional reliability of this model, the present study examined mitogenic responses to pheno...
ORGANISM(S): Homo sapiens 
2021-04-20 | GSE149228 | GEO
TranscriptomicsHuman hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver [Rat Liver Experiments]
High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR) activator, have been shown to produce hepatocellular tumors in rodents by a mitogenic mode of action (MOA) involving CAR activation. The effect of 1 week dietary treatment with NaPB on liver weight and histopathology...
ORGANISM(S): Rattus rattus 
2014-08-29 | E-GEOD-57057 | biostudies-arrayexpress
Sort   by:  
 Page size