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ProteomicsMulti-omic Evaluation of PLK1 Inhibitor—Onvansertib—in Colorectal Cancer Spheroids
Polo-like kinase 1 (Plk1) is a serine/threonine kinase involved in regulating the cell cycle. It is activated by aurora kinase B along with the cofactors Borealin, INCE, and survivn. Plk1 is involved in the development of resistances to chemotherapeutics such as doxorubicin, taxol, and gemcitabine. ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054453 | Pride
Colorectal cancer Lipidomics Cell cycle Spheroids Proteomics Spatial lipidomics Plk-1 inhibition Mass spectrometry imaging 
ProteomicsComparison of monoculture to coculture colon cancer cell-line generated spheroids
Chromatogram library generated of pooled sample. Coculture spheroids formed from fibroblast and colon cancer cell lines, and monoculture spheroids formed from the colon cancer cell line HCT116.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-13 | MSV000093395 | MassIVE
ProteomicsFAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids shows Activation of Ferroptotic Death Mechanism
Colorectal cancer (CRC) is projected to become the third most diagnosed and third most fatal cancer in the United States by 2024, with early onset CRC on the rise. Research is constantly underway to discover novel therapeutics for the treatment of various cancers to improve patient outcomes and surv...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050987 | Pride
Phosphoproteomics Mass spectrometry Colorectal cancer Cancer Proteomics Data-independent acquisition Spheroids 
ProteomicsPhosphoproteome of a patient-matched cell line model of colon cancer metastasis
The contributions of phosphorylation-mediated signaling networks to colon cancer metastasis are poorly defined. To better understand the role of constitutive signaling alterations in cancer progression, the global phosphoproteomes of the SW480 and SW620 cell lines were compared by LC-MS/MS. These pa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080864 | MassIVE
ProteomicsPhosphoproteome of a patient-matched cell line model of colon cancer metastasis
The contributions of phosphorylation-mediated signaling networks to colon cancer metastasis are poorly defined. To better understand the role of constitutive signaling alterations in cancer progression, the global phosphoproteomes of the SW480 and SW620 cell lines were compared by LC-MS/MS. These pa...
ORGANISM(S): Homo sapiens (Human) 
2017-01-06 | PXD003708 | Pride
Consitutive signaling Sw620 Lymph node metastasis Phosphorylation Sw480 
TranscriptomicsSystems-wide RNAi analysis of CASP8AP2 / FLASH
We have used a combination of RNAi based functional and molecular genomic approaches to investigate in detail two proteins required for the survival of CRC cells. Set1 has 22 samples, 10 siNeg controls, 6 siRNA transfections for FLASH and NUP62 each. Set2 has 67 samples, siNeg controls at timepoint:...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-29405 | biostudies-arrayexpress
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