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ProteomicsThe Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Li...
ORGANISM(S): Mus Musculus 
PXD045477 |
ProteomicsDiverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecu...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038754 |
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