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TranscriptomicsHuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and positive breast cancer
Analysis of RNA immunoprecipitation of HuR, a RNA binding protein (RBP), in breast cancer cell lines. This approach, utilizing RNA immunoprecipitation hybridized to microarray (RIP-Chip), provides global identification of putative endogenous mRNA targets of different RBPs. HuR is an RBP that binds ...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17820 | biostudies-arrayexpress
TranscriptomicsUnstressed HeLa cells and ELAVL1/HuR knock down conditions: polyA RNA-Seq, small RNA-Seq, and PAR-CLIP
Post-transcriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA stability regulator. We used PAR-CLIP, a method based on RNA-protein crosslinking, to identify transcriptome wide ~26,000 HuR ...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-29943 | biostudies-arrayexpress
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63466 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human anaplastic meningioma IOMM-Lee cells following silencing of HuR (Human antigen R) gene expression by siRNA
The human anaplastic meningioma IOMM-Lee cells were cultured in Dulbecco’s modified Eagle’s medium (Life Technologies, Carlsbad, California, USA) supplemented with 10% fetal bovine serum, 100 U/ml penicillin, and 100 mg/ml streptomycin, at 37°C in 20% O2 (5% CO2). HuR silencing was achieved by ...
ORGANISM(S): Homo sapiens 
2017-07-01 | E-MTAB-4999 | biostudies-arrayexpress
ProteomicsMolecular Glue Degraders of HuR to Treat BRAF-Mutant Colorectal Cancer
BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all colorectal cancer (CRC) patients, and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as Encorafenib are ineffective due to MAP kinase pathway reactivation driven by BRAF dimeriza...
ORGANISM(S): Homo Sapiens 
2026-04-19 | PXD077365 |
UnknownPost-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1.
Not available
S-EPMC6993928 | biostudies-literature
ProteomicsMolecular Glue Degraders of the RNA Binding Protein HuR to Treat BRAF-Mutant Colorectal Cancer
BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all colorectal cancer (CRC) patients, and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as Encorafenib are ineffective due to MAP kinase pathway reactivation driven by BRAF dimeriza...
ORGANISM(S): Homo Sapiens 
2025-12-21 | PXD072281 |
ProteomicsRNA pull-down-Confocal Nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases a-Synuclein levels
RNA-protein interactions are central to all gene expression processes and contribute to a variety of human diseases. Therapeutic approaches targeting RNA-protein interactions have shown promising effects on some diseases that are previously regarded as ‘incurable’. Here we developed a fluorescent on...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025617 | Pride
Rp-cona Α-synuclein Hur Parkinson’s disease Mir-7 
UnknownInhibition of the RNA Regulator HuR Mitigates Spinal Cord Injury by Potently Suppressing Post-Injury Neuroinflammation.
Not available
S-EPMC12046946 | biostudies-literature
UnknownThree New Monotypic Genera of the Caloplacoid Lichens (Teloschistaceae, Lichen-Forming Ascomycetes).
Not available
S-EPMC4630424 | biostudies-literature
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