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RNA-protein interactions are central to all gene expression processes and contribute to a variety of human diseases. Therapeutic approaches targeting RNA-protein interactions have shown promising effects on some diseases that are previously regarded as ‘incurable’. Here we developed a fluorescent on...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025617 | Pride
The molecular basis of astrocyte differentiation and maturation is poorly understood. As microRNAs have important roles in cell fate transitions, we set out to study their function during the glial progenitor cell (GPC) to astrocyte transition. Inducible deletion of all canonical microRNAs in GPCs i...
ORGANISM(S): Mus musculus 
Differentially expressed genes after mir-7 over-expression
Extracellular pH (pHe) is lower in many tumors than in the corresponding normal tissue. Acidic tumor microenvironment has been shown to facilitate epithelial mesenchymal transition (EMT) and tumor metastasis, while the mechanisms underlying tumor acidic microenvironment-induced tumor cell metastasis...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD016524 | Pride
Gene expression of myeloma cell lines with miR-7 transduction
Investigation of genome-wide effects (transcriptome profiling) and direct targets of mir-9 in MCF-7 cells transfected with mir-9 in two dosages (1X and 2X) Following transfections of mir-9 or control miRNA mimics, total RNA was isolated and microarray profiling was performed.
ORGANISM(S): Homo sapiens 
Next generation sequencing facilitates quantitative analysis of colonic tissue from miR-7 deficiency and WT mice with IBD mice, and human colonic epithelial cells transfected-with NC/miR-7 inhibitor/miR-7 inhibitor plus Erlotinib following LPS treatment
miR-21 is overexpressed in breast cancer cells. Knock-down of miR-21 cause apoptosis and decreased cell proliferation. To identify miR-21 regulated cancer-pathways in MCF-7 cells, we knocked-down miR-21 and performed microarray. RNA was harvested from MCF-7 cells 24 hours transfection of anti-contro...
ORGANISM(S): Homo sapiens 
Genome-wide maps in MCF-7 cells with or without MiR-9 overexpression.
Expression data from Huh7.5 hepatoma cells transfected with 100 nM miR-7 mimic
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