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TranscriptomicsDrosophila melanogaster transcriptional profiling over life span: Indy vs. Controls
Transcriptional profiling of Indy long lived flies and controls over the course of their entire lifespan. Mutations in the Indy gene extend life span in Drosophila melanogaster. This study investigates the changes in gene expression over time in Indy206 flies heterozygous over Canton-S (Indy206/CS)...
ORGANISM(S): Drosophila melanogaster 
2010-05-22 | E-GEOD-13872 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Brassica lines
Transcription profiling of Brassica rapa, Brassica oleracea and Brassica napus I and II The nuclear genomes of the resynthesised B. napus lines should be identical but, as one (B. napus I) involved a cross of B. oleracea onto B. rapa, and the other (B. napus II) involved a cross of B rapa onto B. o...
ORGANISM(S): Brassica rapa 
2010-05-19 | E-GEOD-15915 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal melanocytes and melamoma cell lines reveal defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts synchronized and treated with 1.5 Gy irraditation to identify primary transcriptional regulation of cell-cycle-regulated genes upon DNA damage
The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the express...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7075 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human diploid fibroblasts after ionizing radiation damage
Cell cycle arrest and transcriptional responses to ionizing radiation (IR)-induced DNA damage were quantified in telomerase-expressing human diploid fibroblasts. Assays of clonal expansion established 1.5 Gy IR as the D0 dose in three fibroblast lines and this dose was used in all subsequent analyse...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6902 | biostudies-arrayexpress
TranscriptomicsCross-platform comparability of microarray data
To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms and methods to accommodate this variability. RNA expression data were generated in seven labo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2458 | biostudies-arrayexpress
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