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UnknownEpidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era.

Background

Ventilation management may differ between COVID-19 ARDS (COVID-ARDS) patients and patients with pre-COVID ARDS (CLASSIC-ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC-ARDS also exist in COVID-ARDS.

Methods

Individual patient ...
S-EPMC11330602 | biostudies-literature
UnknownPreventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK.
The liver's high metabolic activity and detoxification functions generate reactive oxygen species, mainly through oxidative phosphorylation in the mitochondria of hepatocytes. In contrast, it also has a potent antioxidant mechanism for counterbalancing the oxidant's effect and relieving oxidative st...
S-EPMC8698360 | biostudies-literature
UnknownPAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
The liver controls metabolic homeostasis in response to fasting and refeeding periods. Glucokinase (GCK) adjusts hepatic glucose phosphorylation to blood glucose levels, acting as a glucose sensor. Our objective was to determine whether PAS kinase (PASK), a nutrient sensor, could be affecting the ex...
S-EPMC6056484 | biostudies-literature
UnknownPAS kinase deficiency reduces aging effects in mice.
Several signaling pathways may be affected during aging. All are regulated by nutrient levels leading to a decline in mitochondrial function and autophagy and to an increase in oxidative stress. PAS Domain Kinase (PASK) is a nutrient and bioenergetic sensor. We have previously found that PASK plays ...
S-EPMC7041766 | biostudies-literature
UnknownPas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver.
Metabolic dysfunction in the liver is the cause of numerous pathologies, which are associated with an altered redox state. PASK (PAS Domain Kinase) is a nutrient and bioenergetic sensor. We contend that PASK could act as an oxidative stress sensor in liver and/or control the metabolic balance, playi...
S-EPMC6138710 | biostudies-literature
UnknownStorage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
Glucagon-like peptide 1 (GLP-1) and PAS kinase (PASK) control glucose and energy homeostasis according to nutritional status. Thus, both glucose availability and GLP-1 lead to hepatic glycogen synthesis or degradation. We used a murine model to discover whether PASK mediates the effect of exendin-4 ...
S-EPMC8399311 | biostudies-literature
UnknownUNIversity students' LIFEstyle behaviours and Mental health cohort (UNILIFE-M): study protocol of a multicentre, prospective cohort study.

Introduction

Students enrolling in higher education often adopt lifestyles linked to worse mental health, potentially contributing to the peak age onset of mental health problems in early adulthood. However, extensive research is limited by focusing on single lifestyle behaviours, including ...
S-EPMC12815070 | biostudies-literature
UnknownAssessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019.

Background

Health-care needs change throughout the life course. It is thus crucial to assess whether health systems provide access to quality health care for all ages. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019), we measured the Healthcare Acc...
S-EPMC9666426 | biostudies-literature
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.

Introduction

Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of...
S-EPMC12519944 | biostudies-literature
UnknownOutcomes of urgent gastrointestinal-related procedures in Latin America (LATAM-URG): a prospective multicentre study.

Background

Urgent abdominal operations represent a large proportion of surgical care and are associated with substantial morbidity and mortality. Evidence is scarce from low- and middle-income countries (LMICs), including Latin America (LA). The lack of regionally representative outcomes dat...
S-EPMC12921494 | biostudies-literature
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