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The Human Silencing Hub (HuSH) complex is a complex that silences retrotransposable elements invertebrates. Here, we identify a second HuSH complex, designated HuSH2, which is centered aroundTASOR2, a paralog of the core TASOR protein in HuSH. Our findings reveal that HuSH and HuSH2 localize todisti...
ORGANISM(S): Homo sapiens (Human) 
2024-09-24 | PXD049085 | Pride
Investigate the functions of HUSH complex in embryonic stem cells
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes
Genome surveillance through repression of intronless mobile elements by the HUSH complex
RNA binding by Periphilin plays an essential role in initiating silencing by the HUSH complex
ZNF638 represses HBV covalently closed circular DNA transcription involving HUSH complex epigenetic silencing
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
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