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TranscriptomicsRecapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-24487 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hutchinson-Gilord progeria syndrome fibroblast cell lines with dominant mutation in the LMNA gene and age-matched normal controls
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease with widespread phenotypic features resembling premature aging. HGPS was recently shown to be caused by dominant mutations in the LMNA gene, resulting in the in-frame deletion of 50 amino acids near the carboxyl terminus of the en...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-3860 | biostudies-arrayexpress
UnknownArsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events.
Not available
S-EPMC5040607 | biostudies-literature
TranscriptomicsNext Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis
Chronic kidney disease (CKD) is the gradual, asymptomatic loss of kidney function and current tests only identify it when significant loss has already happened. Using RNA sequencing in a mouse model of folic acid (FA) induced nephropathy, here we report the identification of 10 genes that track kidn...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-65267 | biostudies-arrayexpress
UnknownZika Virus Circulates at Low Levels in Western and Coastal Kenya.
Not available
S-EPMC7399697 | biostudies-literature
UnknownDurable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor-Modified T Cells After Failure of Ibrutinib.
Not available
S-EPMC5590803 | biostudies-literature
UnknownPatient income level and cancer clinical trial participation.
Not available
S-EPMC3565180 | biostudies-literature
UnknownChallenges for Predictive Modeling With Neural Network Techniques Using Error-Prone Dietary Intake Data.
Not available
S-EPMC11806516 | biostudies-literature
UnknownNeutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant.
Not available
S-EPMC1346878 | biostudies-literature
UnknownBiomarker Panel for Chronic Graft-Versus-Host Disease.
Not available
S-EPMC5012688 | biostudies-literature
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