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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9079 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9074 | MetaboLights
TranscriptomicsComparison of steady state mRNA levels between equine articular cartilage and ten other equine tissues
A tissue survey of gene expression was conducted using microarray-based transcriptional profiling to compare equine articular cartilage to 10 other normal adult horse tissues. The ten comparative tissues were bladder, cerebellum, kidney, liver, lung, lymph node, muscle, placental villous, spleen, a...
ORGANISM(S): Equus caballus 
2011-01-27 | E-GEOD-23862 | biostudies-arrayexpress
TranscriptomicsThe temporal transcriptomic signature of cartilage formation
To study chondrogenesis, we used a chicken limb bud model: We used RNA sequencing, and examined the differences between gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. We sequenced in triplicate at Day 0,1,2,3,4,6,10,15 and also fr...
ORGANISM(S): Gallus gallus 
2023-03-28 | E-MTAB-12770 | biostudies-arrayexpress
TranscriptomicsFetal mesenchymal stromal cells differentiating towards chondrocytes acquire a gene expression profile resembling human growth plate cartilage.
We used human fetal bone marrow-derived mesenchymal stromal cells (hfMSCs) differentiating towards chondrocytes as an alternative model for the human growth plate (GP). Our aims were to study gene expression patterns associated with chondrogenic differentiation to assess whether chondrocytes derived...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-40942 | biostudies-arrayexpress
ProteomicsProteomic evaluation of decellularization of porcine auricular cartilage
This dataset represents protein profiles of porcine ear cartilage before and after decellularization.
ORGANISM(S): Sus Scrofa Domesticus (ncbitaxon:9825) 
2023-12-15 | MSV000093673 | MassIVE
ProteomicsSexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage
Male and female collagen-enriched fraction of cartilage from bovine knees. Full thickness cartilage plugs without subchondral bone were digested with chondroitinase for 24 hours to remove proteoglycans. Cartilage was further decellularized with SDS. LUM1_811145: channels 126, 127, 128 female, chan...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
MSV000092997 | MassIVE
Transcriptomicscircadian clock in cartilage
This experiment investigated the circadian clock in mice cartilage. A microarray time-series was performed using xiphoid tissue (metasternum) from mice in constant darkness. Time points were every 4 hr for 40 hr in total.
ORGANISM(S): Mus musculus 
2013-10-19 | E-MEXP-3780 | biostudies-arrayexpress
TranscriptomicsExpression data from articular and growth plate cartilage
The aim of the current study was to identify molecular markers for articular cartilage that can be used for the quality control of tissue engineered cartilage. Therefore a genom-wide expression analysis was performed using RNA isolated from articular and growth plate cartilage, both extracted from t...
ORGANISM(S): Sus scrofa 
2011-07-28 | E-GEOD-23492 | biostudies-arrayexpress
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