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MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
ProteomicsPeptide Retention Time Prediction for Electrostatic Repulsion-Hydrophilic Interaction Chromatography
Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) is a legacy separation tools developed by Dr. Andrew Alpert and has been used for developing unique separation methods of hydrophilic compounds, including peptides. We employed a proteomics-derived ~170,000 peptide retention data...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095965 | MassIVE
ProteomicsImproved reversed phase chromatography of hydrophilic peptides from spatial and temporal changes in column temperature
Reversed phase chromatography is an established method for peptide separation and frequently coupled to electrospray ionization-mass spectrometry for proteomic analysis. Column temperature is one parameter that influences peptide retention and elution, but it is often overlooked as its implementatio...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2017-04-10 | PXD006112 | Pride
Liquid chromatography Bsa Hydrophilic peptide Mass spectrometry Temperature Hela Isoaspartic acid 
ProteomicsCoolTip: Low-Temperature Solid-Phase Microextraction Tip for Capturing Hydrophilic Phosphopeptides
We developed a simple temperature controlled desalting strategy to cover from hydrophilic to hydrophobic peptides. Reversed-phase solid-phase extraction (SPE) techniques are commonly used for shotgun-proteomics using liquid chromatography/tandem mass spectrometry. In reversed-phase chromatography, s...
ORGANISM(S): Homo Sapiens (human) 
2021-10-28 | PXD027112 | JPOST Repository
ProteomicsCoolTip: Low-Temperature Solid-Phase Microextraction Tip for Capturing Hydrophilic Phosphopeptides: 2
We developed a simple temperature controlled desalting strategy to cover from hydrophilic to hydrophobic peptides. Reversed-phase solid-phase extraction (SPE) techniques are commonly used for shotgun-proteomics using liquid chromatography/tandem mass spectrometry. In reversed-phase chromatography, s...
ORGANISM(S): Homo Sapiens (human) 
2021-10-28 | PXD028871 | JPOST Repository
UnknownSynthetic polymer nanoparticles with antibody-like affinity for a hydrophilic peptide.
Not available
S-EPMC2815330 | biostudies-literature
UnknownElectrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes.
Not available
S-EPMC6920922 | biostudies-literature
UnknownCm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae).
Not available
S-EPMC4763977 | biostudies-literature
ProteomicsFormic acid and Acetic acid for peptide LC-MS
Despite the general acceptance of formic acid as the additive of choice for peptide reversed-phase LC-MS/MS applications, some still argue that the selection of acetic acid represents a better option. To settle this debate, we investigated both the difference in MS sensitivity and chromatographic be...
ORGANISM(S): Homo Sapiens (human) 
2022-12-10 | PXD029416 | JPOST Repository
ProteomicsTwo-step peptide solubilization increases coverage in high-sensitivity nanoHILIC/MS/MS-based proteomics
Nanoscale hydrophilic-interaction chromatography coupled with tandem mass spectrometry (nanoHILIC/MS/MS) is a promising alternative to reversed-phase liquid chromatography (RPLC) for proteomics, but its application is limited by the poor solubility of peptides in organic solvent-rich sample solution...
ORGANISM(S): Homo Sapiens (human) Bos Taurus 
2025-05-08 | PXD059304 | JPOST Repository
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