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ProteomicsChemical-proteomics profiling of reactive cysteines near a hydrophobic pocket
This project investigates reactive cysteine residues located near hydrophobic pockets in proteins, features conserved in autopalmitoylated proteins. S-palmitoylation is a post-translational modification that regulates protein localization and function, and has been implicated in neurological, metabo...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD070770 | Pride
Autopalmitoylation Hydrophobic pockets Chemical proteomics Reactive cysteines Druggable sites 
UnknownProbing the functional hotspots inside protein hydrophobic pockets by in situ photochemical trifluoromethylation and mass spectrometry.
Not available
S-EPMC10866368 | biostudies-literature
UnknownRecognition of two hydrophobic pockets in the KIX domain of CBP by FOXO4 transactivation domain.
Not available
S-EPMC12698673 | biostudies-literature
UnknownButtressing ligand-binding pockets in de novo designed NTF2-like domains.
Not available
S-EPMC12514758 | biostudies-literature
Genomics
The tryptophan-binding pockets of Arabidopsis ARGONAUTE1 facilitate amplified RNA interference via SGS3
PRJNA1327840 | ENA
UnknownSolubilization of Hydrophobic Catalysts Using Nanoparticle Hosts.
Not available
S-EPMC5848072 | biostudies-literature
UnknownThe Thermodynamics of Anion Complexation to Nonpolar Pockets.
Not available
S-EPMC10668596 | biostudies-literature
UnknownDeepDrug3D: Classification of ligand-binding pockets in proteins with a convolutional neural network.
Not available
S-EPMC6375647 | biostudies-literature
UnknownApplication of Photoinduced Electron Transfer with Copper Nanoclusters toward Finding Characteristics of Protein Pockets.
Not available
S-EPMC6648241 | biostudies-literature
UnknownInteraction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets.
Not available
S-EPMC6787928 | biostudies-literature
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