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GenomicsThe effects of IDH1 R132H autopalmitoylation on gene expressions in U87 cells
The effects of IDH1 R132H autopalmitoylation on gene expressions in U87 cells
PRJNA1084071 | ENA
TranscriptomicsThe effects of IDH1 R132H autopalmitoylation on gene expressions in U87 cells
Gain-of-function mutations of isocitrate dehydrogenase 1 (IDH1) lead to neomorphic enzymatic activities and the production of oncometabolite R-2-hydroxyglutarate (2-HG), contributing to the tumorigenesis of several human cancers. It has been shown that fatty acid biosynthesis is required for the gro...
ORGANISM(S): Homo sapiens 
2025-11-18 | GSE260937 | GEO
UnknownAutopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Not available
S-EPMC4798901 | biostudies-literature
UnknownMutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms.
Not available
S-EPMC4140262 | biostudies-literature
UnknownA fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening.
Not available
S-EPMC6445550 | biostudies-literature
ProteomicsChemical-proteomics profiling of reactive cysteines near a hydrophobic pocket
This project investigates reactive cysteine residues located near hydrophobic pockets in proteins, features conserved in autopalmitoylated proteins. S-palmitoylation is a post-translational modification that regulates protein localization and function, and has been implicated in neurological, metabo...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD070770 | Pride
Autopalmitoylation Hydrophobic pockets Chemical proteomics Reactive cysteines Druggable sites 
ProteomicsAbhd17a deficiency enhances Zdhhc7 autopalmitoylation to drive Cav1-Cd36 complex formation and hepatic steatosis in ApoE−/− mice
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent global health burden, yet the post-translational mechanisms governing hepatic lipid homeostasis remain incompletely defined. Here, we identify the depalmitoylase Abhd17a as a critical suppressor of hepatic steatosis thro...
ORGANISM(S): Mus Musculus 
PXD083175 |
TranscriptomicsPolyA-enriched RNA-seq of primary human hepatocyte spheroids treated with small molecule inhibitors targeting TEAD
TEAD1 emerged as an estrogen-sensitive gene that was upregulated in a HFD mouse model and in NAFLD patients. We investigated the roles of TEAD in NAFLD by treating primary human hepatocyte spheroids with two small molecule inhibitors blocking the TEAD/YAP interaction. One small molecule blocks the i...
ORGANISM(S): Homo sapiens 
2024-02-22 | E-MTAB-13207 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Quantitative Analysis of TEAD Palmitoylation Inhibitor TM2 in NCI-H226 cells
Purpose: The goal of this study is to understand the signaling pathway alteration in NCI-H226 cells treated with new TEAD autopalmitoylation inhibitor TM2, and to further validate TEAD inhibitor for specifity in TEAD-YAP interuption. Methods: Mesothelioma cell line NCI-H226 was chosen to be treated ...
ORGANISM(S): Homo sapiens 
2024-05-01 | GSE203421 | GEO
TranscriptomicsNext Generation Sequencing Quantitative Analysis of TEAD Palmitoylation Inhibitor MGH-CP1 in MDA-MB-231 cells
Purpose: The goal of this study is to understand the signaling pathway alteration inMDA-MB-231cells treated with TEAD autopalmitoylation inhibitor MGH-CP1, and to further validate TEAD inhibitor for specifity in TEAD-YAP interuption. Methods:Breast cancer cell line MDA-MB-231 was chosen to be treate...
ORGANISM(S): Homo sapiens 
2022-09-11 | GSE177052 | GEO
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