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MetabolomicsMulti-Omic Analysis and Platelet Function Distinguish Treatment Responses to Hydroxytyrosol in Cardiovascular Risk
Many polyphenols have been recognized for their antioxidant and health benefits. The present study attempted, for the first time, to determine the effects of daily oral intake of β-cyclodextrin-encapsulated hydroxytyrosol (HT) on plasma platelet reactivity and proteomic and metabolomic profiles of p...
2025-06-30 | MTBLS12336 | MetaboLights
ProteomicsPolyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
Supplementation of the mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-08-12 | PXD033684 | Pride
Hydroxytyrosol  hippocampus  intrauterine growth restriction  brain  pig  proteome  tmt labelling 
TranscriptomicsTranscriptional profile Lactobacillus plantarum WCFS1 : Hydroxytyrosol treated cells
Whole genome transcriptional profiling was used to characterize the response of Lactobacillus plantarum WCFS1 human isolate during challenge with hydroxytyrosol. Twelve independent experiments were performed and mixed at random in groups of four for total of three RNA samples. Whole genome transcrip...
ORGANISM(S): Lactiplantibacillus plantarum 
2020-06-17 | GSE90714 | GEO
GenomicsHYDROXYTYROSOL IN CARDIOVASCULAR RISK
MULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK
PRJEB84474 | ENA
TranscriptomicsDifferentially expressed genes after treatment with hydroxytyrosol in DMBA-induced rat breast tumors
The aim of this study was to compare the gene expression profile changes of DMBA-induced rat breast tumors after treatment with hydroxytyrosol (a natural compound from virgin olive oil). To this end, a cDNA microarray experiment was performed (Affymetrix’s Rat Genome 230 2.0 array). This gene expres...
ORGANISM(S): Rattus norvegicus 
2009-06-01 | GSE15944 | GEO
ProteomicsMULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK
Many polyphenols, such as hydroxytyrosol (HT), have been recognized for their antioxidant and cardiovascular (CV) health benefits. To address the efficacy of HT, the present study aimed to identify the relevant mechanisms, associated with high-CV risk. Plasma unbiased multi-omics data were compared ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-07-01 | PXD060820 | Pride
Human plasma Hydroxytyrosol Mouse ev enriched plasma 
UnknownA Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol.
Not available
S-EPMC6767028 | biostudies-literature
TranscriptomicsHydroxytyrosol, a component of olive oil for breast cancer prevention in women at high risk of cancer
This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt β-catenin and other pathways involved in cancer stem cell renewal, DNA repair, cell proliferation and differentiation. Hydroxytyrosol reduced ...
ORGANISM(S): Homo sapiens 
2025-01-03 | GSE285765 | GEO
UnknownEnzymatic Methoxycarbonylation of Tyrosol and Hydroxytyrosol.
Not available
S-EPMC11432353 | biostudies-literature
TranscriptomicsDifferentially expressed genes after treatment with hydroxytyrosol in DMBA-induced rat breast tumors
The aim of this study was to compare the gene expression profile changes of DMBA-induced rat breast tumors after treatment with hydroxytyrosol (a natural compound from virgin olive oil). To this end, a cDNA microarray experiment was performed (Affymetrix’s Rat Genome 230 2.0 array). This gene expres...
ORGANISM(S): Rattus norvegicus 
2009-06-01 | E-GEOD-15944 | biostudies-arrayexpress
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