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TranscriptomicsTranscription profiling of human neutrophil and PBMC gene expression data from Jobs Syndrome individuals
Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8507 | biostudies-arrayexpress
GenomicsGene expression analysis in endothelial cells derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
Gene expression analysis in endothelial cells derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
PRJNA578735 | ENA
GenomicsAnalysis of gene expression in skin fibroblasts derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
Analysis of gene expression in skin fibroblasts derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
PRJNA578738 | ENA
TranscriptomicsA mouse model of HIES reveals pro and anti-inflammatory functions of STAT3
Mutations of STAT3 underlie the autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus, hematopoietic stem cell transplantation (HSCT), might be a reasonable therapeutic strategy in this disease. However, STAT3 also has critical function...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-55607 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in endothelial cells derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
Autosomal-dominant hyper-IgE syndrome (AD-HIES, Job’s syndrome) is a primary immunodeficiency caused by loss of function mutations in signal transducer and activator of transcription 3 (STAT3), a critical regulator of diverse cellular processes. In addition to immunological deficits, patients experi...
ORGANISM(S): Homo sapiens 
2020-08-12 | GSE139188 | GEO
TranscriptomicsAnalysis of gene expression in skin fibroblasts derived from patients with Autosomal-dominant hyper-IgE syndrome (AD-HIES)
Autosomal-dominant hyper-IgE syndrome (AD-HIES, Job’s syndrome) is a primary immunodeficiency caused by loss of function mutations in signal transducer and activator of transcription 3 (STAT3), a critical regulator of diverse cellular processes. In addition to immunological deficits, patients experi...
ORGANISM(S): Homo sapiens 
2020-08-12 | GSE139202 | GEO
UnknownGeneration of human induced pluripotent stem cell lines (NIHTVBi011-A, NIHTVBi012-A, NIHTVBi013-A) from autosomal dominant Hyper IgE syndrome (AD-HIES) patients carrying STAT3 mutation.
Not available
S-EPMC6957122 | biostudies-literature
UnknownHyper-IgE syndrome with STAT3 mutation: a case report in Mainland China.
Not available
S-EPMC2871547 | biostudies-literature
UnknownHyper-IgE syndrome: a case report.
Not available
S-EPMC10849427 | biostudies-literature
UnknownTNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome.
Not available
S-EPMC6063472 | biostudies-literature
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