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ProteomicsEstablishment of titration-based control of DNA replication in Escherichia coli
Escherichia coli couples the initiation of DNA replication with cell size by modulating the activity of the replication initiator protein DnaA. The activity of DnaA is regulated both by its interconversion between an active and inactive form and by its titration on chromosomal binding sites. Whereas...
ORGANISM(S): Escherichia coli 
2026-09-10 | PXD075568 | Pride
Hyper-replicative stress Dnaa-atp/dnaa-adp switch Replication forks Dnaa boxes Dnaa Titration-based control of dna replication 
UnknownHyper-mitogenic drive coexists with mitotic incompetence in senescent cells.
Not available
S-EPMC3562309 | biostudies-literature
UnknownLimited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.
Not available
S-EPMC5519195 | biostudies-literature
OtherProliferative stress in hematopoietic stem cells partially drives their functional decline during aging by DNA methylation imprints
Aging of hematopoietic stem cells (HSCs) has been shown to drive many aging phenotypes including immune dysfunction, anemia, malignancies, and more. It has been proposed that HSC aging can be driven by their proliferation, however, the dynamics of this phenomenon and how it relates to stress induced...
ORGANISM(S): Mus musculus 
2024-12-11 | GSE274387 | GEO
GenomicsProliferative stress in hematopoietic stem cells partially drives their functional decline during aging by DNA methylation imprints
Proliferative stress in hematopoietic stem cells partially drives their functional decline during aging by DNA methylation imprints
PRJNA1146326 | ENA
TranscriptomicsChronological Aging of Yeast in the Absence of Caloric Restriction: Cell Immobilization Uncouples Reproduction from Metabolism
Studies using yeast have advanced our understanding of both replicative and chronological aging, leading to the discovery of longevity genes that have homologues in higher eukaryotes. Chronological lifespan in yeast is conventionally defined as the lifespan of a non-dividing cell. To date, this para...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-31 | E-GEOD-21187 | biostudies-arrayexpress
UnknownA Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in Saccharomyces cerevisiae.
Not available
S-EPMC7263696 | biostudies-literature
UnknownActin nucleators safeguard replication forks by limiting nascent strand degradation.
Not available
S-EPMC9882250 | biostudies-literature
UnknownDefining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Not available
S-EPMC3919593 | biostudies-literature
UnknownActin nucleators safeguard replication forks by limiting nascent strand degradation.
Not available
S-EPMC10325910 | biostudies-literature
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