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ProteomicsMitochondrial responses during hyperammonemia
Ammonia is a cytotoxic metabolite with pleotropic molecular and metabolic effects in non-hepatic tissue/cells targeting mitochondrial oxidative function that may contribute to post-mitotic senescence. Global molecular responses were determined by analysis of unbiased data followed by experimental va...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-17 | PXD026955 | Pride
Cytotoxic Ammonia Pca Hyperammonemia Portacaval anastomosis 
ProteomicsHyperammonemia-dependent and independent skeletal muscle phosphoproteomic responses during exercise
Phosphorylation of skeletal muscle proteins mediates cellular signaling and adaptive responses to exercise. Bioinformatic and machine learning approaches identified preclinical models that recapitulate human exercise responses. Feature selection showed that muscles from treadmill running mice and ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-25 | PXD031372 | Pride
Mass spectrometry Hyperammonemia Skeletal muscle Phosphoproteomics 
ProteomicsMetabolic reprogramming during hyperammonemia targets mitochondrial function and post-mitotic senescence
Ammonia is a cytotoxic metabolite with pleotropic molecular and metabolic effects in non-hepatic tissue/cells targeting mitochondrial oxidative function that may contribute to post-mitotic senescence. Global molecular responses were determined by analysis of unbiased data followed by experimental va...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2021-11-22 | PXD027754 | Pride
Cytotoxic Ammonia Pca Hyperammonemia Portacaval anastomosis 
ProteomicsDysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction by inhibiting sirtuin mediated deacetylation
Perturbed metabolism of ammonia, an endogenous cytotoxic molecule, causes mitochondrial dysfunction with decreased nicotinamide adenine dinucleotide (NAD+) in skeletal muscle. Consistent with our previous report of enrichment of NAD metabolism and sirtuin pathways during hyperammonemia, NAD+-depende...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD033430 | Pride
Multiomic Mitochondria Redox ratio Hyperacetylation Sirtuin 
ProteomicsIntegrated molecular landscape perturbations underlie cellular responses during hyperammonemia
Ammonia is a cytotoxic molecule generated during cellular functions and by the gut microbiome. Dysregulated ammonia metabolism initiates a hyperammonemic stress response (HASR). Hyperammonemia occurs in many chronic diseases but there is limited understanding of the overall consequences of HASR. A c...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-27 | PXD025321 | Pride
C2c12 myotubes Skeletal muscle Hyperammonemia 
TranscriptomicsGlutaminase 2 Knockdown Reduces Hyperammonemia and Associated Lethality of Urea Cycle Disorder Mouse Model
Urea cycle disorders with hyperammonemia remain difficult to treat and eventually necessitate liver transplantation. An ornithine transcarbamylase defect (Otcspf-ash) mouse model, a model of urea cycle disorder, was used to test whether knockdown of a key glutamine metabolism enzyme glutaminase 2 (G...
ORGANISM(S): Mus musculus 
2022-06-07 | GSE179342 | GEO
GenomicsIdentification of hyperammonemia-induced changes in the cerebral transcriptome and proteome
Identification of hyperammonemia-induced changes in the cerebral transcriptome and proteome
PRJNA669876 | ENA
UnknownHyperornithinemia, Hyperammonemia, and Homocitrullinuria Syndrome Causing Severe Neonatal Hyperammonemia.
Not available
S-EPMC6323011 | biostudies-literature
GenomicsGlutaminase 2 Knockdown Reduces Hyperammonemia and Associated Lethality of Urea Cycle Disorder Mouse Model
Glutaminase 2 Knockdown Reduces Hyperammonemia and Associated Lethality of Urea Cycle Disorder Mouse Model
PRJNA743310 | ENA
GenomicsIntegrated molecular landscape perturbations underlie cellular responses during hyperammonemia [ATAC-seq]
Integrated molecular landscape perturbations underlie cellular responses during hyperammonemia [ATAC-seq]
PRJNA720401 | ENA
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