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Soluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3beta...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD033127 | Pride
Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model
C-tail hyperphosphorylation activates PTEN oncogenic properties
Ruxolitinib mediated paradox JAK2 hyperphosphorylation is due to the protection of activation loop phosphotyrosines from phosphatases
Ruxolinitib was approved by the FDA for the treatment of JAK2-V617F positive myelofibrosis. Unexpectedly, treatment of JAK2-V617F expressing cells with ruxolitinib causes paradoxical hyperphosphorylation of JAK2 at Tyr1007/1008 sites. The mechanism of ruxolitinib-induced JAK2 hyperphosphorylation is...
ORGANISM(S): Mus musculus 
2025-02-01 | GSE284481 | GEO
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