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This study investigates the molecular mechanisms of hypertrophic cardiomyopathy (HCM), a common genetic heart disease where the link between cardiac remodeling and immune response is not fully understood. We aimed to identify novel diagnostic biomarkers and explore transcriptomic alterations in peri...
ORGANISM(S): Homo sapiens 
This study utilized TMT to characterize the cardiac proteomic differences between patients with hypertrophic cardiomyopathy and controls.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-28 | MSV000091821 | MassIVE
This study used TMT-pro method to look for phosphoproteomic differences in heart tissue of patients with hypertrophic cardiomyopathy and controls
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-28 | MSV000091822 | MassIVE
MicroRNAs negatively regulate gene expression and may serve as biomarkers for human cardiomyopathy. In the domestic cat, hypertrophic cardiomyopathy (HCM) represents the most common primary cardiomyopathy. In humans, the etiology of HCM is linked to mutations in genes of contractile muscle proteins,...
ORGANISM(S): Felis catus 
We developed a 5'RNA-seq methodology to concurrently assess gene expression and start-site usage changes. We applied this methodology to study hypertrophic cardiomyopathy in mice harboring a human deleterious mutation. 5'RNA-seq analysis of transcriptomes from mouse hearts with or without hypertroph...
ORGANISM(S): Mus musculus 
The HipSci project brings together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. In this sub-study we perform RNAseq on iPS lines from Hypertrophic Cardiomyopathy pat...
The project was designed to identify plasma protein biomarkers of hypertrophic cardiomyopathy (HCM) and to specify signaling pathways.
ORGANISM(S): Homo sapiens (Human) 
2025-03-20 | PXD060680 | Pride
Using a high-throughput gene expression profiling technology, we have illuminated novel potential microRNA (miRNA) components of the molecular disease process underlying human hypertrophic cardiomyopathy (HCM). It is hoped that this will fuel future research endeavors that will eventually uncover t...
ORGANISM(S): Homo sapiens 
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