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MetabolomicsWax ester and lipophilic compound profiling of Euglena gracilis by gas chromatography-mass spectrometry: toward understanding of wax ester fermentation under hypoxia
Lipids are being increasingly used as biodiesel feedstock, and several saturated wax esters from Euglena gracilis are candidates for outdoor bulk production. Wax ester fermentation in Euglena is strongly increased by hypoxia, but key events underlying the metabolic shift toward wax ester biosynthesi...
2014-09-04 | MTBLS113 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
TranscriptomicsEffect of NDRG3 or HIF-1α knockdown on cell response to hypoxia
Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1α under hypoxic condition. HIF-1α and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors Gene expressi...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55212 | biostudies-arrayexpress
TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
ProteomicsEndothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Uncontrolled accumulation of pulmonary artery smooth muscle cells (PASMC) to the distal pulmonary arterioles (PAs) is one of the major characteristics of pulmonary hypertension (PH). Cellular senescence contributes to aging and lung diseases associated with PH and links to PH progression. However, t...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033549 | Pride
Twist1 Pulmonary hypertension Hypoxia Endothelial cell Pdgfb Senescence 
TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
TranscriptomicsEffect of NDRG3 overexpression on cell response to hypoxia
Analysis of HeLa cells overexpressing NDRG3 or exposed to hypoxic condition. Gene expression profiles of HeLa cells stably expressing NDRG3 were compared to gene expression profiles of HeLa stable cells expressing mock or hypoxia-mediated gene expression profiles.
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55211 | biostudies-arrayexpress
TranscriptomicsTuning the transcriptional response to hypoxia through HIF prolyl- and asparaginyl-hydroxylase inhibition:Sequencing Data
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an /-heterodimeric transcription factor that regulates the expression of hundreds of genes in a context dependent manner. A hypoxia-sensing component of the HIF system involves oxygen-dependent ca...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-MTAB-4264 | biostudies-arrayexpress
TranscriptomicsIdentifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro
Background: Genes upregulated by low oxygen have been suggested as endogenous markers for tumor hypoxia. Yet, most of the genes investigated have shown inconsistent results, which have led to concerns about their ability to be true hypoxia markers. Previous studies have demonstrated that expression ...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-GEOD-70051 | biostudies-arrayexpress
TranscriptomicsACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxi...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-61286 | biostudies-arrayexpress
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