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ProteomicsHypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics
Hypoxic exposure during development can have a profound influence on offspring physiology, including cardiac dysfunction, yet many reptile embryos naturally experience periods of hypoxia in buried nests. American alligators experimentally exposed to developmental hypoxia demonstrate morphological an...
ORGANISM(S): Alligator Mississippiensis (ncbitaxon:8496) 
2019-05-22 | MSV000083838 | MassIVE
TranscriptomicsEffect of NDRG3 or HIF-1α knockdown on cell response to hypoxia
Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1α under hypoxic condition. HIF-1α and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors Gene expressi...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55212 | biostudies-arrayexpress
TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
TranscriptomicsEffect of NDRG3 overexpression on cell response to hypoxia
Analysis of HeLa cells overexpressing NDRG3 or exposed to hypoxic condition. Gene expression profiles of HeLa cells stably expressing NDRG3 were compared to gene expression profiles of HeLa stable cells expressing mock or hypoxia-mediated gene expression profiles.
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55211 | biostudies-arrayexpress
ProteomicsZea mays under 24 h hypoxia - shotgun of soluble proteins
Maize (Zea mays L.) was hydroponically grown for 14 days and then stressed with hypoxia. Maize roots were sampled after 24 hours and analyzed by mass spectrometry.
ORGANISM(S): Zea mays (Maize) 
2022-05-06 | PXD033386 | Pride
Hypoxia Soluble proteins Shotgun Maize roots 
TranscriptomicsExpression profiling of hypoxic HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells: time course
Analysis of expression changes of cultured HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells subjected to hypoxia (0.5% O2) for 0, 4, 8, 12 hours . Results provide insight to cell type-specific response to hypoxia. HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells were collec...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-18494 | biostudies-arrayexpress
TranscriptomicsTuning the transcriptional response to hypoxia through HIF prolyl- and asparaginyl-hydroxylase inhibition:Sequencing Data
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an /-heterodimeric transcription factor that regulates the expression of hundreds of genes in a context dependent manner. A hypoxia-sensing component of the HIF system involves oxygen-dependent ca...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-MTAB-4264 | biostudies-arrayexpress
ProteomicsEndothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Uncontrolled accumulation of pulmonary artery smooth muscle cells (PASMC) to the distal pulmonary arterioles (PAs) is one of the major characteristics of pulmonary hypertension (PH). Cellular senescence contributes to aging and lung diseases associated with PH and links to PH progression. However, t...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033549 | Pride
Twist1 Pulmonary hypertension Hypoxia Endothelial cell Pdgfb Senescence 
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