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MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
TranscriptomicsDefined hypoxic model timecourse of H37Rv and H37Rv:deltadosR
Background: A significant body of evidence accumulated over the last century suggests a link between hypoxic microenvironments within the infected host and the latent phase of tuberculosis. Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-02-20 | E-GEOD-9331 | biostudies-arrayexpress
TranscriptomicsIxr1 and the Saccharomyces cerevisiae hypoxic response
Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ixr1 null, grown in aerobic, hypoxic conditions and after a hypoxic shift Two biological replicates in two technical replicates for each growth condition
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-13 | E-GEOD-30046 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Candida parapsilosis in low oxygen (hypoxic) conditions in SD media
Whole genome microarray was used to compare the transcriptional profile of C. parapsilosis growing in normoxic (21% oxygen) and hypoxic (1% oxygen) conditions. RNA was isolated from cells grown in SD media at 37°C for 3 h in atmosphere oxygen of 1% oxygen, and labeled with Cy5 or Cy3. Six independe...
ORGANISM(S): Candida parapsilosis 
2010-05-06 | E-GEOD-13722 | biostudies-arrayexpress
TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic RPMI8226 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45388 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic SUDHL4 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45387 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic K562 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45289 | biostudies-arrayexpress
TranscriptomicsEffect of NDRG3 overexpression on cell response to hypoxia
Analysis of HeLa cells overexpressing NDRG3 or exposed to hypoxic condition. Gene expression profiles of HeLa cells stably expressing NDRG3 were compared to gene expression profiles of HeLa stable cells expressing mock or hypoxia-mediated gene expression profiles.
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55211 | biostudies-arrayexpress
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