Sort   by:  
 Page size 
TranscriptomicsGATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental cell signaling pathways have been associated with PDAC development and progr...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-27173 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the intestinal crypts of mice with loss of imprinting
To identify genes differentially expressed in the intestinal crypts between LOI(+) and LOI(-) mice, we performed microarray experiments using RNA extracted from laser capture microdissection, by microdissecting an average of 8,000 crypts from each of 3 LOI(+) and 3 LOI(-) mice. Keywords: genetic mo...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8583 | biostudies-arrayexpress
GenomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [ChIP-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63125 | biostudies-arrayexpress
GenomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [BS-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63123 | biostudies-arrayexpress
TranscriptomicsLarge-scale epigenetic reprogramming is punctuated late during the evolution of pancreatic cancer progression [RNA-Seq]
During pancreatic cancer progression, heterogeneous subclonal populations evolve in the primary tumor that possess differing capacities to metastasize and cause patient death. However, the genetics of metastasis reflects that of the primary tumor, and PDAC driver mutations arise early. This raises t...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63124 | biostudies-arrayexpress
GenomicsEGAD00000000052
Sequencing data from natching Pancreatic Carcinoma samples
EGAD00000000052 | EGA
GenomicsThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97–98%, usually due to widespread metastatic disease. Previous studies indicate that this disease has a complex genomic landscape, with frequent copy number changes and point mutations, but genomic rearrangements have not ...
EGAS00000000064 | EGA
GenomicsMassive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
EGAS00000000029 | EGA
GenomicsMassive genomic rearrangement acquired in a single catastrophic event during cancer development - samples
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
EGAD00001000002 | EGA
TranscriptomicsWidespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four color...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-63601 | biostudies-arrayexpress
Sort   by:  
 Page size