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TranscriptomicsTranscription profiling of E47 targets in the neuroblastoma cell line SK-N-SH at 8 hours and 20 hours
E47 is a basic Helix Loop Helix (bHLH) transcription factor that has important roles in cell fate determination and differentiation of many cell types. In the nervous system E47 heterodimerizes with tissue-specific, pro-neural bHLH transcription factors and activates downstream target genes. To iden...
ORGANISM(S): Homo sapiens 
2006-02-01 | E-MEXP-413 | biostudies-arrayexpress
TranscriptomicsMicroarray of Human astrocytes transduced with lentivirus expressing FGFR3-TACC3 treated with vehicle, FGFR3-TACC3 treated with the FGFR inhibitor PD173074 for 12h, FGFR3-TACC3-K508M treated with vehicle or empty vector treated with vehicle
In order to interrogate the transcriptional changes elicited by FGFR3-TACC3, we expressed the FGFR3-TACC3 fusion protein in human astrocytes and compared the global gene expression profiles of cells treated with a specific inhibitor of FGFR3-TK (PD173074) or vehicle. FGFR3-TACC3 expressing HA were a...
ORGANISM(S): Homo sapiens 
2017-10-17 | E-MTAB-6037 | biostudies-arrayexpress
TranscriptomicsId proteins synchronize stemness and anchorage to the niche of neural stem cells
Stem cell functions require activation of stem cell-intrinsic transcriptional programs as well as intimate extracellular interactions with a niche microenvironment. How the core pluripotency transcriptional machinery controls residency of stem cells in the niche microenvironment is unknown. Here we ...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-36488 | biostudies-arrayexpress
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