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Proteomicsp62 sustains a protumorigenic gene signature in melanoma opposing mRNA-dependent decay
p62/SQSTM1 was identified as a modulator of metastatic genes selectively enriched in melanoma in autophagy independent manner. iTRAQ quantitative proteomic approach was performed in melanoma cell lines (SK-Mel-103 and UACC-62) deficient for p62 to identify downstream effectors of p62. Similar studie...
ORGANISM(S): Homo sapiens (Human) 
2021-10-29 | PXD007000 | Pride
Itraq Melanoma cell lines Lcmsms 
ProteomicsThe RNA Polymerase II factor RPAP1 is critical for Mediator-driven transcription and cell identity
The RNA Polymerase II Associated Protein 1 (RPAP1) is conserved across metazoa and critical for stem cell differentiation in plants, however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of lineage spec...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-10 | PXD007114 | Pride
Cell identity Rna pol ii Rpap1 Mediator 
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