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ProteomicsDefine the interactome of IBTK by Affinity purification coupled with mass spectrometry (AP-MS) and proximity-dependent biotinylation identification (BioID) methods
Affinity purification coupled with mass spectrometry (AP-MS) and proximity-dependent biotinylation identification (BioID) methods are powerful tools to define the interactome for a specific protein bait. Whereas AP-MS results in the identification of proteins that are in a stable complex, BioID labe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD038286 | Pride
Ap-ms Ibtk interactome Bioid 
ProteomicsThe identification of ubiquitination sites of IBTK by shotgun proteomics
Previous study reported that eIF4A1 protein stability is subject to control by the ubiquitin-proteasome pathway, and deubiquitinase USP9X elevated eIF4A1 protein level by promoting eIF4A1 deubiquitination. However, the E3 ubiquitin ligases responsible for eIF4A1 proteolysis is not determined. Our re...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD039031 | Pride
Ibtk Ubiquitination Shotgun 
ProteomicsThe identification of phosphorylation sites of IBTK by shotgun proteomics
Translation is a tightly regulated process, and the mTORC1-S6K signaling axis plays a critical role in this control. Binding of eIF4F to the cap is hindered by eIF4E binding proteins (4EBPs), which, when hypophosphorylated, sequester eIF4E and prevent its association with eIF4G. However, in response...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD038307 | Pride
Ibtk Phosphorylation Shotgun 
UnknownPhysical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.
Not available
S-EPMC2490745 | biostudies-literature
UnknownIBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis.
Not available
S-EPMC6459904 | biostudies-literature
UnknownIBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells.
Not available
S-EPMC5133848 | biostudies-literature
Genomics
CELL TYPE-SPECIFIC EFFECTS OF IBTK ON GENE EXPRESSION AND RNA SPLICING
PRJNA335350 | ENA
TranscriptomicsfourSig: A Method for Determining Chromosomal Interactions in 4C-Seq Data
The ability to correlate chromosome conformation and gene expression gives a great deal of information regarding the strategies used by a cell to properly regulate gene activity. 4C-seq is a relatively new and increasingly popular technology where the set of genomic interactions generated by a singl...
ORGANISM(S): Mus musculus 
2014-02-22 | E-GEOD-50907 | biostudies-arrayexpress
UnknownCRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.
Not available
S-EPMC4447969 | biostudies-literature
GenomicsHomo sapiens
Homo sapiens Transcriptome or Gene expression
PRJNA331098 | ENA
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