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GenomicsIGF2BP3 regulates RNA metabolism during unfolded protein response [RKO iCas9 cells]
IGF2BP3 regulates RNA metabolism during unfolded protein response [RKO iCas9 cells]
PRJNA1223285 | ENA
GenomicsTranscriptome profiling of H1-iCas9 cells grown on laminin and on MEFs
Transcriptome profiling of H1-iCas9 cells grown on laminin and on MEFs
PRJNA516653 | ENA
TranscriptomicsSingle-cell chromatin accessibility atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scATAC-seq data gener...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12714 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scRNA-seq data genera...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12715 | biostudies-arrayexpress
ProteomicsCellular assembly, functional hierarchy, and proteostatic control of the RNA exosome in mouse embryonic stem cells
Most eukaryotic proteins are constituents of multiprotein complexes, yet our understanding of how individual subunits contribute to complex function, assembly and stability remains limited. Here, we utilize a doxycycline-inducible dual guide CRISPR/Cas9 system (iCas9) in mESCs to systematically inve...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD061800 | Pride
Mescs Rna exosome Exosome inducible knockouts Icas9 
UnknownRNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration.
Not available
S-EPMC6707420 | biostudies-literature
TranscriptomicsSystematic genetic perturbation reveals principles underpinning robustness of the epigenetic regulatory network [RNA-Seq]
We profiled gene expression in iCas9-expressing HCEC-1CT and HME1 cells that were either WT or knockout for ARID1A or CREBBP, to determine the cell type variability in expression levels of epigenetic regulators and the transcriptional consequences of epigenetic regulator loss.
ORGANISM(S): Homo sapiens 
2025-03-25 | GSE245297 | GEO
TranscriptomicsSingle-Cell RNAsequencing of Human Naïve Pluripotent Stem Cells to Trophoblast Stem Cells with and without EZH2 inhibition.
Single-Cell RNAsequencing of the conversion of naïve iCas9 Sigma hiPSC line 1 (iCSIG-1 hiPSCs) into trophoblast stem cells with and without EZH2i (Abcam ab146152 UNC1999, EZH2 methyltransferase inhibitor) during 4 days preconversion and during 4 days during conversion (total of 8 days with or withou...
ORGANISM(S): Homo sapiens 
2022-03-23 | GSE176173 | GEO
UnknownGeneration of an inducible dCas9-SAM human PSC line for endogenous gene activation.
Not available
S-EPMC11638181 | biostudies-literature
UnknownInducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal.
Not available
S-EPMC5969550 | biostudies-literature
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