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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
MetabolomicsIDH1 and Glioma knockdown idh1 (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000199 | MetabolomicsWorkbench
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1973 | MetaboLights
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHpos)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1974 | MetaboLights
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (FA_HILICZ)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1967 | MetaboLights
MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
MetabolomicsMetabolomic profiling of IDH1 mutation (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000822 | MetabolomicsWorkbench
Metabolomics2HG concentration in human IDH1m cells
Not available
ORGANISM(S): Homo sapiens 
ST000824 | MetabolomicsWorkbench
MetabolomicsMetabolomic profiling of IDH1 mutation
Not available
ORGANISM(S): Homo sapiens 
ST000821 | MetabolomicsWorkbench
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