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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
MetabolomicsMetabolomic profiling of IDH1 mutation
Not available
ORGANISM(S): Homo sapiens 
ST000821 | MetabolomicsWorkbench
MetabolomicsMetabolomic profiling of IDH1 mutation (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000822 | MetabolomicsWorkbench
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHNeg)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1973 | MetaboLights
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (CSHpos)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1974 | MetaboLights
MetabolomicsIDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids (FA_HILICZ)

Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring an isocitrate dehydrogenase 1 mutation (IDHmut), acquire a different tumor biology and clinical manifestation than those that are IDHWT. Understanding the unique metabolic profile reprogrammed by IDH1 ...

2020-11-24 | MTBLS1967 | MetaboLights
ProteomicsMetabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: an investigation at the protein level
The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA-cycle are...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD016697 | Pride
Proteomics Glioma Idh1 mutation 
ProteomicsEffects of the IDH1 R132H mutation on the energy metabolism: a comparison between tissue and corresponding primary glioma cell cultures
The R132H mutation in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) is the most important prognostic factor for survival of glioma patients. This resulted in many studies investigating the effects of this mutation, including those on energy metabolism. This led to the discovery of a panel o...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024019 | Pride
Idh1 r132h mutation Cell cultures Glioma Proteomics Energy metabolism 
GenomicsIdh1-R132H mutation increases murine hematopoietic progenitors and alters epigenetics.
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequent in human glioblastomas1 and cytogenetically normal acute myeloid leukemias (AML)2. These alterations are gain-of-function mutations in that they drive the synthesis of the M-bM-^@M-^\oncometaboliteM-bM-^@M-^] R-2-hy...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-38687 | biostudies-arrayexpress
TranscriptomicsIDH1 mutation defines methylation class and survival in human glioma
Astrocytoma, oligodendroglioma, oligoastrocytoma, and ependymoma are the main histologic subtypes of glioma. The molecular character of these subtypes has profound implications for understanding their causes and treatment. We describe the epigenetic landscape of these tumor types using novel DNA met...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-20395 | biostudies-arrayexpress
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