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MetabolomicsDynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVES: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics...

2022-08-05 | MTBLS5267 | MetaboLights
ProteomicsUSP14 Promotes Tryptophan Metabolism and Immune Suppression by Stabilizing IDO1 in Colorectal Cancer
IDO1 interacting proteins in two colorectal cancer cells and was subjected to beads, and the beads were washed by buffer and identified by mass spectrometry (MS)
ORGANISM(S): Homo Sapiens 
2022-05-05 | PXD033718 |
GenomicsIdentification of IDO1 depedent genes upon IFN-γ stimulation
Identification of IDO1 depedent genes upon IFN-γ stimulation
PRJNA1314260 | ENA
GenomicsAn adverse tumor-protective effect of IDO1 inhibition
An adverse tumor-protective effect of IDO1 inhibition
PRJNA815336 | ENA
GenomicsAnalysis of HeLa cell transcriptome changes induced by IDO1-metabolism
Analysis of HeLa cell transcriptome changes induced by IDO1-metabolism
PRJNA728450 | ENA
GenomicsGestational gut microbiome-IDO1 axis mediates pregnancy insulin resistance
Gestational gut microbiome-IDO1 axis mediates pregnancy insulin resistance
PRJEB45047 | ENA
GenomicsIDO1 overexpression significantly affects exosomal miRNA subsets derived from osteosarcoma and ordinary osteoblasts
IDO1 overexpression significantly affects exosomal miRNA subsets derived from osteosarcoma and ordinary osteoblasts
PRJNA972006 | ENA
TranscriptomicsIdentification of IDO1 depedent genes upon IFN-γ stimulation
A key mechanism of malignant cell evasion from anti-tumor immunity centers on tryptophan metabolism by indole-2,3-dioxygenase (IDO1). By degrading tryptophan, IDO1 impairs anti-tumor T cell responses, which should be restored by IDO1 inhibitors (IDO1i). All IDO1i have, however, failed their clinical...
ORGANISM(S): Homo sapiens 
2026-01-20 | GSE307099 | GEO
GenomicsTumor endothelial up-regulation of IDO1 limits the response to CD40-stimulating immunotherapy
Tumor endothelial up-regulation of IDO1 limits the response to CD40-stimulating immunotherapy
PRJNA540971 | ENA
GenomicsIdentification of indoleamine 2, 3-dioxygenase 1 (IDO1) regulated genes in human glioblastoma cell line U87
Identification of indoleamine 2, 3-dioxygenase 1 (IDO1) regulated genes in human glioblastoma cell line U87
PRJNA733217 | ENA
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