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MetabolomicsIFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma
Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...
2026-05-31 | MTBLS14634 | MetaboLights
MetabolomicsIFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma (Glucose Tracer)
Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...
2026-05-31 | MTBLS14641 | MetaboLights
MetabolomicsIFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma (CAR-T Metabolites)
Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...
2026-05-31 | MTBLS14640 | MetaboLights
TranscriptomicsRole for ISGF3II in the Antiviral Activity of IFN-gamma
Type-I (e.g. IFN-alpha, IFN-beta) and type-II IFNs (IFN-gamma) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-gamma is thought to do so only through STAT1 homodimers while type-I IFNs act...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-25113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-1925 | biostudies-arrayexpress
TranscriptomicsExosomes isolated from M.tb infected cells modulate macrophage response to IFN-gamma
we studied the role of exosomes isolated from M.tb infected macrophages in modulating the macrophage response to IFN-γ. Nimblegen microarray gene expression studies were used to compare the suppression of IFN-γ inducible genes by exosomes relative to the virulent strain of M.tuberculosis. Overall ou...
ORGANISM(S): Mus musculus 
2011-06-05 | E-GEOD-29731 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal rat microglia after IFN-gamma activation
IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Experiment Overall Design: Primary rat microglia cultures were established and maintained for 15 days. For activation studies, fresh media containi...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6353 | biostudies-arrayexpress
TranscriptomicsT-bet-depended but IFN-gamma-independent genes in GVHD
Given T-bet is a master regulator for Th1 differentiation that produce IFN-gamma, underlining mechanisms accounted for the distinct GVHD outcomes caused by T-bet- versus IFN-gamma-deficient donor T cells are unclear. We hypothesize that GVHD is regulated by T-bet-dependent but IFN-gamma-independe...
ORGANISM(S): Mus musculus 
2014-10-30 | E-MTAB-2198 | biostudies-arrayexpress
TranscriptomicsRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Interferon-gamma (IFN-gamma) is approved as a drug to treat chronic granulomatous disease and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. These primary immunodeficiencies involve defects in neutrophils/polymorphonuclear cells. Neutrophils mature in the bone marrow and then e...
ORGANISM(S): Homo sapiens 
2017-08-31 | E-MTAB-5690 | biostudies-arrayexpress
TranscriptomicsIFN-alpha- and IFN-gamma-regulated transcription in MEFs derived from wild type mice or littermates expressing STAT1F77A
Transcriptional profiling of mouse primary embryonic fibroblasts (MEFs) from wild type (WT) and knockin littermates expressing STAT1F77A (KI). For both genotypes, untreated control cells were compared to cells treated with IFN-alpha or IFN-gamma. Two condition experiments; untreated versus IFN trea...
ORGANISM(S): Mus musculus 
2014-01-12 | E-GEOD-49441 | biostudies-arrayexpress
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