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Interferon-alpha/beta-receptor (IFNAR) signal defects were recently identified to contribute to sporadic Parkinson’s disease (PD) with dementia (PDD). Mice lacking interferon-beta (IFNβ) develop PDD-like disease; however, the phenotypic, cellular, and molecular impacts of IFNAR1 loss in vivo have no...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD037113 | Pride
IFNAR1 Signaling in NK Cells Promotes Persistent Virus Infection
Distinct Impact of Neuronal and Astrocytic IFNAR1 Loss in Parkinson-like Dementia
Effect of Ifnar1 Knockdown in a mouse model of Cerebral Interferonopathy
IFNAR1-dependent transcriptomic changes in fibroblasts upon skin organoid development
Role of TLR7 and IFNAR1 in lacrimal gland autoimmunity in NOD mice
The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1−/−), and STAT1 knockout (STAT1−/−) mice infected...
ORGANISM(S): Mus musculus 
Acute metaplastic injury of wild-type and Ifnar1-/-mice.
ISG induction in ∆7bp IFNAR2 mutant, IFNAR1 KO and wild type THP1.
p38α activation-mediated IFNAR1 downregulation by tumor derived factors induced neutrophil-attracting chemokines production
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