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TranscriptomicsExpression data from IgE+ and IgG1+ B lymphocytes in mice infected with Nippostrongylus brasiliensis
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE cells in these memory responses is particularly unclear. IgE B-cell differentiation is characterized by a transient GC phase, a bias towards the plasma cell (PC) ...
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-49033 | biostudies-arrayexpress
MetabolomicsThe impact of IgE in gut and serum metabolomes in a murine experimental model of allergic enteritis
Not available
ORGANISM(S): Mus musculus 
ST002236 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human neutrophil and PBMC gene expression data from Jobs Syndrome individuals
Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8507 | biostudies-arrayexpress
MetabolomicsLipidomics study of curcumin and epigallocatechin gallate on IgE-mediated degranulation of RBL-2H3 cells
Not available
ORGANISM(S): Rattus norvegicus 
ST002384 | MetabolomicsWorkbench
ProteomicsIgE reactivity profiling in an asthma affected cohort
Background: Most asthmatic patients have high serum levels of IgE directed against common environmental allergens such as house dust mite, animal danders and moulds. However the presence of specific IgE against individual allergens alone does not account for asthma. Many individuals are atopic but n...
ORGANISM(S): Homo sapiens 
2012-01-03 | E-GEOD-20020 | biostudies-arrayexpress
ProteomicsProtein profiling of human serum against a panel of allergens.
Current diagnostics for allergies, such as skin prick and radioallergosorbent tests, do not allow for inexpensive, high-throughput screening of patients. Additionally, extracts used in these methods are made from washed pollen that lacks pollen surface materials that may contain allergens. We soug...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-177 | biostudies-arrayexpress
ProteomicsIgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells
In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports the toxin hypothesis, showing that MCs and IgE-related type 2 immune responses can enhance host defense aga...
ORGANISM(S): Homo sapiens (Human) Apis mellifera (Honeybee) 
2021-11-25 | PXD023851 | Pride
Honeybee venom  host defense  ige  mast cells  toxin hypothesis 
TranscriptomicsMicroRNA profiling of mouse bone marrow-derived mast cells during mucosal differentiation and IgE-mediated activation
The aim of this study was to investigate microRNA expression pattern and its functional relevance on the commitment toward mucosal differentiation and on IgE-mediated activation of mast cells. To identify microRNA genes the expression of which change during the differentiation and activation of muri...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-24321 | biostudies-arrayexpress
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
ProteomicsIgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus
Best known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-10 | PXD019107 | Pride
Human allergies Mast cells Ige antibodies Host defense Bacterial infection 
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