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ProteomicsIgM Abs to Apoptosis-associated Determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
Natural antibodies, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis but their role in innate immunity remains poorly understood. Herein, we show that the immune response to neo-antigenic determinants on apoptotic thymocytes is dom...
ORGANISM(S): Mus musculus 
2009-02-23 | E-GEOD-14958 | biostudies-arrayexpress
ProteomicsBaseline serum anti-glycan antibodies of 113 subjects in a clinical trial of PROSTVAC-VF, a therapeutic cancer vaccine [Validation IgM 1:50]
Purpose: There is evidence that therapeutic cancer vaccines can lengthen survival for some cancer patients, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. Thi...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-42175 | biostudies-arrayexpress
ProteomicsBaseline serum anti-glycan antibodies of 28 subjects in a clinical trial of PROSTVAC-VF, a therapeutic cancer vaccine [Training IgM 1:50]
Purpose: There is evidence that therapeutic cancer vaccines can lengthen survival for some cancer patients, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. Thi...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-42020 | biostudies-arrayexpress
UnknownMultimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199.
Not available
S-EPMC9398157 | biostudies-literature
ProteomicsGrass carp serum IgM LC-ESI-MS/MS and MALDI-MS
Glycosylation represents a major post-translational modification of proteins that can influence their structure and function.Telesot immunoglobulin M (IgM) is an especially important product of the immune system because it is the main Abs in seum and plays a critical role against defense infection. ...
ORGANISM(S): Ctenopharyngodon idella 
2018-11-29 | PXD010308 | Pride
Lc-ms/ms) Grass carp Immunoglobulin m Maldi-ms 
ProteomicsDefining the Structural Features of Complement-Active IgM: Surface Ag linker comparison
Immunoglobulin mu (IgM) is a class of mammalian antibodies that are critical for the early stages of adaptive immunity and are the most potent activators of the classical complement cascade. While the relationship between IgM and complement has been appreciated for decades, the structural transition...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-02 | PXD056670 | Pride
Igm Hdx-ms Antibody-antigen interaction 
ProteomicsDefining the Structural Features of Complement-Active IgM: 3-state comparison of IgG
Immunoglobulin mu (IgM) is a class of mammalian antibodies that are critical for the early stages of adaptive immunity and are the most potent activators of the classical complement cascade. While the relationship between IgM and complement has been appreciated for decades, the structural transition...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-02 | PXD056918 | Pride
Igm Hdx-ms Antibody-antigen interaction Igg 
ProteomicsDefining the Structural Features of Complement-Active IgM: 3-state comparison
Immunoglobulin mu (IgM) is a class of mammalian antibodies that are critical for the early stages of adaptive immunity and are the most potent activators of the classical complement cascade. While the relationship between IgM and complement has been appreciated for decades, the structural transition...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-02 | PXD056897 | Pride
Igm Hdx-ms Antibody-antigen interaction 
ProteomicsProteic characterization of the IgM triplet involved in the diagnosis of congenital toxoplasmosis
Congenital toxoplasmosis is a fetal infection following the transplacental transmission of Toxoplasma gondii in a mother who seroconverted during pregnancy. Neonatal diagnosis has recently been improved through the identification by L’Ollivier et al. and Peyclit et al. of a congenital toxoplasmosis ...
ORGANISM(S): Toxoplasma gondii 
2025-12-08 | PXD060424 | Pride
2d gel Toxoplasma gondii Immunoproteomics Igm triplet Lc-ms/ms 
ProteomicsGenetic exchange in leishmania is facilitated by IgM natural antibodies.
Proteomics of IgM-mediated clumped vs control parasites.
ORGANISM(S): Leishmania major strain Friedlin 
2023-08-20 | PXD038652 | Pride
Igm Genetic exchange Leishmania 
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