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Preanalytical impacts on protein stability by IHC evaluation
Integrative Assessment of RNA-seq and IHC: Linking Tumor Biomarkers and Microenvironment
This study aimed to assess the correlation between RNA sequencing (RNA-seq) and immunohistochemistry (IHC) in detecting key cancer biomarkers across solid tumors, and then, to establish RNA-seq thresholds that accurately reflect clinical IHC classifications. Expression levels of nine biomarkers—ESR1...
ORGANISM(S): Homo sapiens 
2025-08-06 | GSE293591 | GEO
The main goal of this study is to explore the proteomic expression in prophylactic salpingooophorectomy specimens, obtained from highly selected cohort of patients at risk of developing a high-grade serous ovarian carcinoma (HGSOC), because of a hereditary (BRCA 1 or 2 mutation) or a documented fami...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD020024 | Pride
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
Brimonidine protects IHC ribbon synapses and SGNs from noise-induced hearing loss
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