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ProteomicsRevisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
The NAD⁺-dependent deacetylase sirtuin 1 (Sirt1) is known to regulate the tumor suppressor p53 via deacetylation, but the structural basis of the protein-protein interaction between full-length Sirt1 and p53 has so far remained elusive. We apply an integrated approach, combining structural mass spe...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072665 | Pride
Sirtuin 1 Cross-linking Mass spectrometry P53 
ProteomicsPeptide centric detection of cross-linked peptides using PASEF, MeroX, and Skyline
Cross-linking mass spectrometry (XL-MS) has evolved into a pivotal technique for probing protein interactions, with recent ad-vancements significantly enhancing its analytical potential. This technical note presents advancements in cross-linking mass spec-trometry (XL-MS) through the implementation ...
ORGANISM(S): Bos Taurus 
2024-05-13 | PXD047307 | panorama
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