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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
TranscriptomicsRNA-seq of IL-4 stimulated human keratinocytes
In this study we aim to determine the role of IL-4/STAT6 in gene expression in human keratinocytes using RNA-sequencing approach. Human keratinocytes were cultured for 2 or 5 days with calcium chloride to induce terminal differentiation as determined by the expression of epidermal differentiation co...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-59275 | biostudies-arrayexpress
TranscriptomicsmiRNA regulation by interleukin-4 (IL-4) in chronic lymphocytic leukemia (CLL)
miRNA expression profiles of CLL cells and normal B cells (NBC) treated for 18 hr with 10 ng/ml IL-4, compared with culture with nothing (Ctrl) and the basal (Pre) samples. 16 CLL patients (8 Pre samples, 15 Ctrl samples, 15 IL-4 samples), 3 NBC (3 Ctrl samples, 3 IL-4 samples)
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-62137 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression of livers of wild type and IL-4/IL-13-/- mice after carbon tetrachloride-induced injury
Global analysis of differentially expressed genes of livers of wild type and IL-4/IL-13-/- two days after carbon tetrachloride treatment. Total RNA obtained from isolated livers from vehicle and carbon tetrachloride administered wild type and IL-4/IL-13-/- mice.
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of IL-10+IL-4+ versus IL-10_IL-4+ cells from Foxp3null mice.
Comparison of IL-10+IL-4+ versus IL-10_IL-4+ cells from Foxp3null mice, sorted by secreted cytokine capture staining.
ORGANISM(S): Mus musculus 
2012-03-15 | E-MTAB-948 | biostudies-arrayexpress
TranscriptomicsPathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
Polymorphisms in the interleukin-4 receptor ? chain (IL-4R?) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R? has been associated with severe asthma, especially i...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-18010 | biostudies-arrayexpress
TranscriptomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2014-12-16 | E-MTAB-3163 | biostudies-arrayexpress
GenomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress
no omics definedTranscription profiling of human Vg9/Vd2 T cells after 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21
Hver2.1.1 microarrays containing ~15,000 genes were used to characterize the gene expression profiles of Vg9/Vd2 T cells upon 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21.
ORGANISM(S): Homo sapiens 
2007-03-21 | E-MEXP-763 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CH1 B-cells upon stimulation either with anti-IgM, IL-4 or with a combination of anti-IgM and IL-4
We have studied CH1 cells that undergo G1 arrest upon anti-IgM treatment after 16 hrs of stimulation. First we studied the differential gene expression under anti-IgM and IL-4 stimulation condition individually and in combination, and this revealed the affected genes to be directly or indirectly pla...
ORGANISM(S): Mus musculus 
2010-01-19 | E-MTAB-82 | biostudies-arrayexpress
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