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ModelsKessler2025 - IL-6 and IL-22 pathway in human hepatocytes
IL-6 and IL-22 pathway in human hepatocytes
2025-11-14 | MODEL2509100001 | BioModels
TranscriptomicsTranscription profiling of mouse IL-10 -/- macrophages treated with LPS/LPS plus IL10 reveals a transcriptional repressor and co-repressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptiona...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9509 | biostudies-arrayexpress
TranscriptomicsTime-series of IL-6 stimulated primary mouse hepatocytes
External stimulations of cells by hormones, growth factors or cytokines activate signal transduction pathways that subsequently induce a rearrangement of cellular gene expression. The representation and analysis of changes in the gene response is complicated, and essentially consists of multiple lay...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21031 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of the anti-inflammatory effects of PDTC on IL-6 signaling in HepG2 cells
Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts a wide range of cellular, physiological and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in STAT3 activation and downstream signaling. Here, a transcr...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-14632 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers from INFgamma-/- and conditional SOCS3-/- mice treated with different cytokines to study the role of SOCS3 in IL-6 signaling pathway.
Changes in mouse liver mRNA profiles following intraperitoneal cytokine injection. Either interferon-gamma-/-, albumin-cre(-) Socs3(w/fl) mice, or albumin-cre(+) Socs3(-/fl) mice were injected with either phosphate-buffered saline, interferon-gamma, or interleukin-6, and livers taken after 4h.
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-369 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from IL-6-/- and IL-10-/- mutants treated with IL-10 or IL-6 stimulation in the presence of LPS
IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from cont...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow-derived macrophages from SOCS3+/+ and SOCS3-/- mice to study the effects of SOCS3 on the transcriptional responses of the macrophages to IL-6.
Effects of SOCS3 on the transcriptional response of bone marrow-derived macrophages to IL-6. Fetal liver cells from SOCS3+/+ or SOCS3-/- embryos were used to reconstitute recipient mice. Donor derived bone marrow from these mice was differentiated to macrophages. Macrophages were either unstimulate...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-411 | biostudies-arrayexpress
TranscriptomicsCooperative Signaling Through the STAT3 and NF-kB Pathways in Subtypes of DLBCL
The activated B cell-like (ABC) subgroup of diffuse large B cell lymphoma (DLBCL) is characterized by constitutive activation of the NF-êB pathway. Here we show that the NF- êB pathway induces the expression of the cytokines IL-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of to...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-10009 | biostudies-arrayexpress
ProteomicsQuantitative proteomics reveals the protective effects of Huangqi decoction against intrahepatic cholestasis by inhibiting NF-κB/IL-6/STAT3 signaling pathwa
Intrahepatic cholestasis (IC) is a common symptom of liver diseases but with limited treatment. Huangqi decoction (HQD), a classic herbal medicine, has shown protective effects against IC. In this study, the iTRAQ-based quantitative proteomics was performed to investigate the potential mechanism of ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-13 | PXD014882 | Pride
Intrahepatic cholestasis  huangqi decoction  proteomics  nf-κb  il-6  stat3 
TranscriptomicsBiological and molecular characterization of CMA03/06, a newly established interleukin-6 independent variant of the CMA03 human myeloma cell line.
We performed a biological and molecular characterization of the novel human multiple myeloma cell line CMA03/06, an IL-6-independent variant of CMA03 cell line previously established in our Institution. We showed that the CMA03/06 cells grows in the absence of IL-6 with a doubling time comparable t...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-39685 | biostudies-arrayexpress
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