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MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
TranscriptomicsEffect of IL-11 on gene expression in JEG-3 and HTR-8/SVneo trophoblastic cells
IL-11 increases the invasiveness of JEG-3 cells while, reduces the invasiveness of HTR-8/SVneo cells. This study examines the effect of IL-11 on gene expression in trophobalstic cell models viz. JEG-3 and HTR-8/SVneo cells to resolve the controversies associated with the IL-11 mediated regulation o...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-31608 | biostudies-arrayexpress
ProteomicsA proteomics investigation of cigarette smoke exposed Wistar rats revealed improved anti-inflammatory effects of the cysteamine nanoemulsions delivered via inhalation
Cigarette smoking is the major cause of chronic inflammatory diseases such as Chronic Obstructive Pulmonary Disease (COPD). It is paramount to develop pharmacological interventions and delivery strategies against the cigarette smoke (CS) associated oxidative stress in COPD. This study in Wistar rats...
ORGANISM(S): Rattus Norvegicus 
PXD033559 | panorama
TranscriptomicsEffect of LIF and IL-6 on gene expression in JEG-3 and HTR-8/SVneo trophoblastic cells
Both leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) increase the invasiveness of JEG-3 and HTR-8/SVneo cells. This study examines the effect of LIF and IL-6 on gene expression in trophoblastic cell models viz. JEG-3 and HTR-8/SVneo cells to decipher the molecular basis of the increase in ...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-36202 | biostudies-arrayexpress
TranscriptomicsVectorial secretion of interleukin-8 (IL-8 or CXCL8) mediates homeostatic effects on the intestinal epithelium via apically located CXCR1
CXCL8 is produced by many cell types including epithelial, endothelial, fibroblasts and macrophages in response to TLR recognition of microbe-associated molecular patterns (MAMPs) or inflammatory cytokines and recruits phagocytes from the vasculature to sites of infection via interaction with its co...
ORGANISM(S): Homo sapiens 
2014-06-28 | E-GEOD-30364 | biostudies-arrayexpress
ProteomicsAssociation of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease
Purpose: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface; however, the upstream immune mechanisms contributing to DED are complex and unclear. This study aimed to identify differentially expressed tear fluid proteins in patients with DED and elucidate the underlying di...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075862 | Pride
Tear proteomics Neutrophil degranulation Histones Ocular surface Dry eye And inflammation 
ProteomicsAssociation of IL-8 and IL-18 Expression with Histone-Associated NETosis in Aqueous-Deficient and Evaporative Dry Eye Disease
Purpose: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface; however, the upstream immune mechanisms contributing to DED are complex and unclear. This study aimed to identify differentially expressed tear fluid proteins in patients with DED and elucidate the underlying di...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075754 | Pride
Tear proteomics Neutrophil degranulation Histones Ocular surface Dry eye And inflammation 
ModelsSenescence Associated Secretory Phenotype
Cells and tissues are exposed to stress from numerous sources. Senescence is a protective mechanism that prevents malignant tissue changes and constitutes a fundamental mechanism of aging. It can be accompanied by a senescence associated secretory phenotype (SASP) that causes chronic inflammation. W...
11863 | Cell Collective
GenomicsEffect of IL-8 and VEGFA on polarization of tumor-associated macrophages
Effect of IL-8 and VEGFA on polarization of tumor-associated macrophages
PRJNA1192969 | ENA
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