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ProteomicsmicroRNA-4331 promotes TGEV-induced mitochondrial damage via targeting RB1, up-regulating IL1RAP, and activating p38 MAPK pathway in vitro
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and up-regulate miR-4331 level. So miR-4331 may play an...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2017-12-15 | PXD008174 | Pride
Micror-4331  mitochondrial damage  proteomics  transmissible gastroenteritis virus  rb1  il1rap  p38 mapk 
ProteomicsIL1RAP augments cysteine metabolism to promote ferroptosis resistance and metastasis in Ewing sarcoma
Aggressive cancer cells must adapt and overcome oxidative stress encountered during the metastatic cascade to successfully disseminate. In this work, a combination of proteomic approaches is used to identify the IL1 receptor accessory protein (IL1RAP) as an in vitro suppressor of anoikis (detachment...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-25 | PXD019009 | Pride
Tmt Cysteine metabolism Il1rap Ewing sarcoma 
UnknownIL1RAP potentiates multiple oncogenic signaling pathways in AML.
Not available
S-EPMC5987926 | biostudies-literature
UnknownMicroRNA-142 improves IL1RAP CAR-T cell activity in acute myeloid leukemia.
Not available
S-EPMC12613351 | biostudies-literature
UnknownThe Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.
Not available
S-EPMC7897808 | biostudies-literature
TranscriptomicsCombined inhibition of IL-1, IL-33 and IL-36 signaling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of Systemic Sclerosis
Background: The IL-1 receptor accessory protein (IL1RAP) is an essential co-receptor required for signaling through the IL-1, IL-33 and IL-36 receptors. Here, we investigate the antifibrotic potential of the combined inhibition of these cytokines by an anti-IL1RAP antibody to provide a scientific ba...
ORGANISM(S): Mus musculus 
2024-04-30 | GSE255031 | GEO
UnknownProteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.
Not available
S-EPMC8563374 | biostudies-literature
TranscriptomicsPost-Hoc Trial and Preclinical Data Identify IL1RAP as a Tumor Microenvironment Vulnerability to Improve Chemoimmunotherapy Sensitivity in Pancreatic Cancer
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) remains highly resistant to chemotherapy and immunotherapy due to a tumor microenvironment (TME) dominated by myeloid-stromal immunosuppressive circuitries and T-cell dysfunction. Key mediators of this chemoimmunoresistance are interleukin-1 (IL-...
ORGANISM(S): Mus musculus 
2026-04-27 | GSE310710 | GEO
GenomicsPost-Hoc Trial and Preclinical Data Identify IL1RAP as a Tumor Microenvironment Vulnerability to Improve Chemoimmunotherapy Sensitivity in Pancreatic Cancer
Post-Hoc Trial and Preclinical Data Identify IL1RAP as a Tumor Microenvironment Vulnerability to Improve Chemoimmunotherapy Sensitivity in Pancreatic Cancer
PRJNA1366971 | ENA
UnknownIL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells.
Not available
S-EPMC11325815 | biostudies-literature
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