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GenomicsIL-33/IL1RL1 (ST2) signalling drives immune suppression in HPV-mediated epithelial hyperplasia
IL-33/IL1RL1 (ST2) signalling drives immune suppression in HPV-mediated epithelial hyperplasia
PRJNA1267010 | ENA
GenomicsAmphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to inhibit antitumor immunity
Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to inhibit antitumor immunity
PRJNA795342 | ENA
GenomicsscGEX/scTCR-Seq of CD44+ cytotoxic T cells in LCMV-infected Wildtype and Il1rl1-ExAB-/- mice
scGEX/scTCR-Seq of CD44+ cytotoxic T cells in LCMV-infected Wildtype and Il1rl1-ExAB-/- mice
PRJNA841968 | ENA
OtherIL-33/IL1RL1 (ST2) signalling drives immune suppression in HPV-mediated epithelial hyperplasia
Interleukin 33 (IL-33), an alarmin cytokine binding to IL1RL1 (ST2) receptor, plays a pleiotropic and controversial role in cancer. Using a human papillomavirus (HPV) E7 oncoprotein-mediated murine model of cutaneous epithelial hyperplasia, we systematically characterised the interactions of epithel...
ORGANISM(S): Mus musculus 
2026-09-23 | GSE297947 | GEO
UnknownInteraction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection.
Not available
S-EPMC7522988 | biostudies-literature
TranscriptomicsAmphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to inhibit antitumor immunity
We demonstrated that IL-33 induced strong CD8+ T cell antitumor immune responses characterized by robust clonal expansion and vigorous functional diversification. Nonetheless, IL-33 also produced intense regulatory T cell (Treg) accumulation in the TME, dominated by the IL1RL1+ Treg subset. We furth...
ORGANISM(S): Mus musculus 
2023-08-30 | GSE193189 | GEO
UnknownA functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.
Not available
S-EPMC5579262 | biostudies-literature
TranscriptomicsscGEX/scTCR-Seq of CD44+ cytotoxic T cells in LCMV-infected Wildtype and Il1rl1-ExAB-/- mice
To study the effect of IL-33 sensing on CD8 T cell differentiation during acute infection with lymphocytic choriomeningitis virus (LCMV), activated CD44+ CTLs were flowcytometrically sorted from infected C57BL/6 wildtype and Il1rl1 gene-targeted mice (Il1rl1-ExAB-/-) and subjected to combined single...
ORGANISM(S): Mus musculus 
2023-10-17 | GSE204693 | GEO
UnknownPhenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.
Not available
S-EPMC4289095 | biostudies-literature
UnknownAssociation between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population.
Not available
S-EPMC9701900 | biostudies-literature
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